Search
Now showing items 21-25 of 25
Involvement of SNPs in miR-3117 and miR-3689d2 in Childhood Acute Lymphoblastic Leukemia Risk
(Board, 2018-04-01)
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that ...
Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia
(Springer Nature, 2014-11-04)
Methotrexate (MTX) is an effective and toxic chemotherapeutic drug in the treatment of pediatric acute lymphoblastic leukemia(ALL). In this prospective study, we aimed to identify metabolic and genetic determinants of MTX ...
Potential relationship between single nucleotide polymorphisms used in forensic genetics and diseases or other traits in European population
(Springer, 2015-03-13)
Single nucleotide polymorphisms (SNPs) are an interesting option to facilitate the analysis of highly degraded DNA by allowing the reduction of the size of the DNA amplicons. The SNPforID 52-plex panel is a clear example ...
A Genome-Wide Study of Single-Nucleotide Polymorphisms in MicroRNAs and Further In Silico Analysis Reveals Their Putative Role in Susceptibility to Late-Onset Alzheimer's Disease.
(Springer Nature, 2020-09-06)
Late-onset Alzheimer's disease (LOAD) is a neurodegenerative disorder of growing relevance in an aging society for which predictive biomarkers are needed. Many genes involved in LOAD are tightly controlled by microRNAs ...
Impact of polymorphisms in apoptosis-related genes on the outcome of childhood acute lymphoblastic leukaemia
(Wiley, 2018-05-29)
Despite intensification of therapy, 20% of children with acute lymphoblastic leukaemia (ALL) relapse (Ceppi et al, 2015). The different response to chemotherapy may be partially explained by inherited genetic variants, ...