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The Golgi as an Assembly Line to the Autophagosome
(Elsevier, 2020-06)
Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles ...
Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis
(Nature, 2020-01-15)
The photoacoustic effect is generated when a variable light interacts with a strongly light-absorbing material. In water, it may produce hot bubbles and shock waves that could affect the integrity of nearby cellular ...
HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
(Public Library Science, 2014-07)
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism ...
The Myth of The Annular Lipids
(MDPI, 2022-10-22)
In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the ...
LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton
(Frontiers Media, 2021-04-01)
LUZP1 is a centrosomal and actin cytoskeleton-localizing protein that regulates both ciliogenesis and actin filament bundling. As the cytoskeleton and cilia are implicated in metastasis and tumor suppression, we examined ...
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
(Taylor & Francis, 2018-05-07)
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have ...
Virion Structure and In Vitro Genome Release Mechanism of Dicistrovirus Kashmir Bee Virus
(American Society For Microbiology, 2021-06)
Infections with Kashmir bee virus (KBV) are lethal for honeybees and have been associated with colony collapse disorder. KBV and closely related viruses contribute to the ongoing decline in the number of honeybee colonies ...
Exploring The Role Of Genome And Structural Ions In Preventing Viral Capsid Collapse During Dehydration
(IOP Publishing, 2018-03-14)
Even though viruses evolve mainly in liquid milieu, their horizontal transmission routes often include episodes of dry environment. Along their life cycle, some insect viruses, such as viruses from the Dicistroviridae ...
Adenylate Cyclase Toxin Promotes Internalisation of Integrins and Raft Components and Decreases Macrophage Adhesion Capacity
(Public Library of Science, 2011-02-23)
Bordetella pertussis, the bacterium that causes whooping cough, secretes an adenylate cyclase toxin (ACT) that must be post-translationally palmitoylated in the bacterium cytosol to be active. The toxin targets phagocytes ...
A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines
(Nature Publishing, 2018-09-17)
Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects ...