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Multivalency Transforms SARS-CoV-2 Antibodies Into Ultrapotent Neutralizers
(Nature, 2021-06-16)
SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies
can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin
protomer as a modular subunit to drive ...
Antibiotic Resistance in Agricultural Soil and Crops Associated to the Application of Cow Manure-Derived Amendments from Conventional and Organic Livestock Farms
(Frontiers Media, 2021-02-23)
he application of organic amendments to agricultural soil can enhance crop yield, while improving the physicochemical and biological properties of the recipient soils. However, the use of manure-derived amendments as ...
Aberrant Synaptic PTEN in Symptomatic Alzheimer's Patients May Link Synaptic Depression to Network Failure
(Frontiers Media, 2021-05-11)
In Alzheimer's disease (AD), Amyloid beta (A beta) impairs synaptic function by inhibiting long-term potentiation (LTP), and by facilitating long-term depression (LTD). There is now evidence from AD models that A beta ...
Economic and Environmental Assessment of Bacterial Poly(3-Hydroxybutyrate) Production from the Organic Fraction of Municipal Solid Waste
(Springer, 2021-05-19)
The management of municipal solid waste is a major logistic and environmental problem worldwide. Nonetheless, the organic fraction of municipal solid waste (OFMSW) is a valuable source of nutrients which can be used for a ...
Patient-Specific iPSC-Derived Cellular Models of LGMDR1
(Elsevier, 2021-04-08)
Limb-girdle muscular dystrophy recessive 1 (LGMDR1) represents one of the most common types of LGMD in the population, where patients develop a progressive muscle degeneration. The disease is caused by mutations in calpain ...
Agricultural Soils Amended with Thermally-Dried Anaerobically-Digested Sewage Sludge Showed Increased Risk of Antibiotic Resistance Dissemination
(Frontiers Media, 2021-04-28)
The application of sewage sludge (SS) to agricultural soil can help meet crop nutrient requirements and enhance soil properties, while reusing an organic by-product. However, SS can be a source of antibiotic resistance ...
Ascertaining the initiation of epidemic resurgences: an application to the COVID-19 second surges in Europe and the Northeast United States
(The Royal Society, 2021-10-06)
[EN]Assessing a potential resurgence of an epidemic outbreak with certainty is as important as it is challenging. The low number of infectious individuals after a long regression, and the randomness associated with it, ...
Reflections and Insights on the Evolution of the Biological Remediation of Contaminated Soils
(Frontiers Media, 2021-09-16)
The field of soil biological remediation was initially focused on the use of microorganisms. For organic contaminants, biostimulation and bioaugmentation were the strategies of choice. For heavy metals, bioremediation was ...
Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
(Elsevier, 2022-01-16)
[EN] Global analysis of protein phosphorylation by mass spectrometry proteomic techniques has emerged in the last decades as a powerful tool in biological and biomedical research. However, there are several factors that ...
Preformulation Studies of a Stable PTEN-PDZ Lipopeptide Able to Cross an In Vitro Blood-Brain-Barrier Model as a Potential Therapy for Alzheimer's Disease
(Springer, 2020-08-04)
PurposeAmyloid beta (A beta) drives the accumulation of excess Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) at synapses, inducing synaptic depression and perturbing memory. This recruitment of PTEN to ...