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p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1
(Public Library Science, 2021-11-10)
[EN]During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the ...
Metformin Reduces Potassium Currents and Prolongs Repolarization in Non-Diabetic Heart
(MDPI, 2022-05-27)
Metformin is the first choice drug for the treatment of type 2 diabetes due to positive results in reducing hyperglycaemia and insulin resistance. However, diabetic patients have higher risk of ventricular arrhythmia and ...
TensioBot: a chatbot assistant for self-managed in-house blood pressure checking
(Springer, 2021-03-15)
[ES] Tensiobot es un chatbot de apoyo asistencial, cuyo objetivo esayudar a los pacientes a realizar sus mediciones de tensión arterial en domicilio. Nuestros resultados muestran que el cumplimiento del programa de control ...
Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.
(Frontiers Media, 2022-10-18)
The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o ...
Conformational Plasticity Underlies Membrane Fusion Induced by an HIV Sequence Juxtaposed to the Lipid Envelope
(Springer Nature, 2021-01-14)
Envelope glycoproteins from genetically-divergent virus families comprise fusion peptides (FPs) that have been posited to insert and perturb the membranes of target cells upon activation of the virus-cell fusion reaction. ...
Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.
(Nature, 2022)
Antibodies against the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein (Env) are considered as nearly pan-neutralizing. Development of vaccines capable of ...
Do calmodulin binding IQ motifs have built-in capping domains?
(Wiley, 2021-08-15)
Most calmodulin (CaM) targets are alpha-helices. It is not clear if CaM induces the adoption of an alpha-helix configuration to its targets or if those targets are selected as they spontaneously adopt an alpha-helical ...
Sex dependent alteration of epigenetic marks after chronic morphine treatment in mice organs
(Elsevier, 2021-06)
Epigenetic marks may be also affected by several factors, such as age, lifestyle, early life experiences and exposure to chemicals or drugs, such as opioids. Previous studies have focused on how morphine epigenetically ...
Loss of benefits after cessation of exercise interventions in nursing home residents: randomized controlled trial follow-up
(Elsevier, 2021-05)
Exercise interventions improve physical fitness, cognitive and affective function, and quality of life among nursing home residents. However, little is known regarding the consequences of cessation of activity, or detraining. ...