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Synthesis of Aminoalkyl Sclareolide Derivatives and Antifungal Activity Studies
(MDPI, 2023-05-12)
Sclareolide was developed as an efficient C-nucleophilic reagent for an asymmetric Mannich addition reaction with a series of N-tert-butylsulfinyl aldimines. The Mannich reaction was carried out under mild conditions, ...
New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine
(MDPI, 2023-04-22)
The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a relatively recent, widely used approach allowing us to modulate the stability, bio-absorption, and overall efficiency of pharmaceutical ...
Featured Reviews in Organic Chemistry
(MDPI, 2023-08-09)
The field of Organic Chemistry represents one of the most traditional areas of chemistry that has delivered many benefits to the community of chemists. This Special Issue of Molecules is a compilation of the most recent ...
Catalytic Asymmetric α-Functionalization of α-Branched Aldehydes
(MDPI, 2023-03-16)
Aldehydes constitute a main class of organic compounds widely applied in synthesis. As such, catalyst-controlled enantioselective α-functionalization of aldehydes has attracted great interest over the years. In this context, ...
Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes
(MDPI, 2021-11-28)
Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of ...
Advances in the Development of Trifluoromethoxylation Reagents
(MDPI, 2021-12-10)
This review provides a short summary of the traditional methods for synthesis of CF3-O-containing compounds, followed by a critical overview of known trifluoromethoxylating reagents, focusing on their preparation, synthetic ...
Asymmetric Synthesis of Tailor-Made Amino Acids Using Chiral Ni(II) Complexes of Schiff Bases. An Update of the Recent Literature
(MDPI, 2020-06-12)
Tailor-made amino acids are indispensable structural components of modern medicinal chemistry and drug design. Consequently, stereo-controlled preparation of amino acids is the area of high research activity. Over last ...
Recommended Tests for the Self-Disproportionation of Enantiomers (SDE) to Ensure Accurate Reporting of the Stereochemical Outcome of Enantioselective Reactions
(MDPI, 2021-05-07)
The purpose of this review is to highlight the necessity of conducting tests to gauge the magnitude of the self-disproportionation of enantiomers (SDE) phenomenon to ensure the veracity of reported enantiomeric excess (ee) ...
A Call for a Change in Policy Regarding the Necessity for SDE Tests to Validate the Veracity of the Outcome of Enantioselective Syntheses, the Inherent Chiral State of Natural Products, and Other Cases Involving Enantioenriched Samples
(MDPI, 2021-06-30)
We wish to draw attention to an important issue concerning scientific practice with regard to enhancing the quality of publications in <i>Molecules</i> (as well as for other journals) [...]
Kitamura Electrophilic Fluorination Using HF as a Source of Fluorine
(MDPI, 2020-04-30)
This review article focused on the innovative procedure for electrophilic fluorination using HF and in situ generation of the required electrophilic species derived from hypervalent iodine compounds. The areas of synthetic ...