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HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress
(Springer, 2022)
HERC2 gene encodes an E3 ubiquitin ligase involved in several cellular processes by regulating the ubiquitylation of different protein substrates. Biallelic pathogenic sequence variants in the HERC2 gene are associated ...
SPANX-A/D protein subfamily plays a key role in nuclear organisation, metabolism and flagellar motility of human spermatozoa
(Nature Publishing Group, 2020-03-27)
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and to a wide ...
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
(The American Society for Clinical Investigation, 2020-07-01)
Cancer cells can develop a strong addiction to discrete molecular regulators, which control the aberrant gene expression programs that drive and maintain the cancer phenotype. Here, we report the identification of the ...
Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
(Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ...
Mycorrhizal-assisted phytoremediation and intercropping strategies improved the health of contaminated soil in a peri-urban area
(Frontiers Media, 2021-07-02)
[EN] Soils of abandoned and vacant lands in the periphery of cities are frequently subjected
to illegal dumping and can undergo degradation processes such as depletion of
organic matter and nutrients, reduced biodiversity, ...
Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
(Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ...
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
(Springer Nature, 2022-02)
[EN] Glycine N-Methyltransferase (GNMT) is a metabolic enzyme that integrates metabolism and epigenetic regulation. The product of GNMT, sarcosine, has been proposed as a prostate cancer biomarker. This enzyme is predominantly ...
Birth and Early Steps of the Organization of Biophysics in Spain
(MDPI, 2022-11-19)
In the 1960s, Biophysics was an unheard of scientific field in Spain, and even outside Spain, the distinction between Biophysics and Molecular Biology was not clear at the time. This paper describes briefly the developments ...
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease
(Wiley, 2020-07-07)
[EN] Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased
in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence
has been associated with age-dependent hepatosteatosis. ...
Toward Diffusion Measurements of Colloidal Nanoparticles in Biological Environments by Nuclear Magnetic Resonance
(Wiley, 2020-09-20)
Protein corona formation on the surface of nanoparticles (NPs) is observed in situ by measuring diffusion coefficients of the NPs under the presence of proteins with a F-19 nuclear magnetic resonance (NMR) based methodology. ...