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Gene Expression Profiling Reveals New Pathways and Genes Associated with Visna/Maedi Viral Disease
(MDPI, 2021-06-15)
Visna/Maedi virus (VMV) is a lentivirus that infects the cells of the monocyte/macrophage lineage in sheep, goats and wild ruminants. Infection with VMV causes a multisystemic inflammatory disorder, which includes pneumonia, ...
Human Papillomavirus (HPV) genotype 18 variants in patients with clinical manifestations of HPV related infections in Bilbao, Spain
(BioMed Central, 2012)
Background:Human papillomavirus (HPV) variants differ in their biological and chemical properties, and therefore,
may present differences in pathogenicity. Most authors classified variants based on the phylogenetic analysis ...
Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction
(MDPI, 2013-08)
Small ruminant lentiviruses (SRLV) are members of the Retrovirus family comprising the closely related Visna/Maedi Virus (VMV) and the Caprine Arthritis-Encephalitis Virus (CAEV), which infect sheep and goats. Both infect ...
Expression analysis of lung miRNAs responding to ovine VM virus infection by RNA-seq
(Biomed Central, 2019-01-18)
BackgroundMicroRNAs (miRNAs) are short endogenous, single-stranded, noncoding small RNA molecules of approximately 22 nucleotides in length. They regulate gene expression posttranscriptionally by silencing mRNA expression, ...
Transcriptomic meta-analysis reveals unannotated long non-coding RNAs related to the immune response in sheep
(Frontiers Media, 2022-11)
Long non-coding RNAs (lncRNAs) are involved in several biological processes, including the immune system response to pathogens and vaccines. The annotation and functional characterization of lncRNAs is more advanced in ...
Whole Transcriptome Approach to Evaluate the Effect of Aluminium Hydroxide in Ovine Encephalon
(Nature, 2020-09-17)
Aluminium hydroxide adjuvants are crucial for livestock and human vaccines. Few studies have analysed their effect on the central nervous system in vivo. In this work, lambs received three different treatments of parallel ...
Identification and characterization of miRNAs in spleens of sheep subjected to repetitive vaccination
(Nature, 2023-04)
Accumulative evidence has shown that short non-coding RNAs such as miRNAs can regulate the innate and adaptive immune responses. Aluminium hydroxide is a commonly used adjuvant in human and veterinary vaccines. Despite its ...
Novel CircRNA Discovery in Sheep Shows Evidence of High Backsplice Junction Conservation
(Springer Nature, 2021-01-11)
Circular RNAs (circRNAs) are covalently closed circular non-coding RNAs. Due to their structure, circRNAs are more stable and have longer half-lives than linear RNAs making them good candidates for disease biomarkers. ...
Identification of sheep lncRNAs related to the immune response to vaccines and aluminium adjuvants
(BMC, 2021-10-28)
[EN]Background Long non-coding RNAs (lncRNAs) are involved in several immune processes, including the immune response to vaccination, but most of them remain uncharacterised in livestock species. The mechanism of action ...
Molecular Signature of Aluminum Hydroxide Adjuvant in Ovine PBMCs by Integrated mRNA and microRNA Transcriptome Sequencing
(Frontiers Media, 2018-10-23)
There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial ...