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Mechanisms Responsible for the Trophic Effect of Beta-Adrenoceptors on the I-to Current Density in Type 1 Diabetic Rat Cardiomyocytes
(Karger, 2013)
Background/Aims: In diabetic ventricular myocytes, transient outward potassium current (I-to) amplitude is severely reduced because of the impaired catecholamine release that characterizes diabetic autonomic neuropathy. ...
Redox regulation of KV7 channels through EF3 hand of calmodulin
(eLife Sciences, 2023-01)
Neuronal KV7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the voltage sensor was reported as a site-mediating redox modulation ...
An Epilepsy-Causing Mutation Leads to Co-Translational Misfolding of the Kv7.2 Channel
(Springer, 2021-05-21)
BACKGROUND: The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. ...
Do calmodulin binding IQ motifs have built-in capping domains?
(Wiley, 2021-08-15)
Most calmodulin (CaM) targets are alpha-helices. It is not clear if CaM induces the adoption of an alpha-helix configuration to its targets or if those targets are selected as they spontaneously adopt an alpha-helical ...
Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade
(Frontiers Media, 2022-04-21)
Increase of deposits of amyloid beta peptides in the extracellular matrix is landmark during Alzheimer's Disease (AD) due to the imbalance in the production vs. clearance. This accumulation of amyloid beta deposits triggers ...
The Crossroad of Ion Channels and Calmodulin in Disease
(MDPI, 2019-01-02)
Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major ...
CaMKII modulates the cardiac transient outward K+ current through their association in non-caveolar membrane rafts
(University of Duisburg-Essen, 2020-01-15)
Background/aims: To test whether the physiological regulation of the cardiac Kv4 channels by the Ca2+/calmodulin-dependent protein kinase II (CaMKII) is restricted to lipid rafts and whether the interactions observed in ...