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Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
(Nature Publishing, 2019-01-29)
New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl ...
Glycans in drug discovery
(Royal Soc Chemistry, 2019-07-26)
Glycans are key players in many biological processes. They are essential for protein folding and stability and act as recognition elements in cell-cell and cell-matrix interactions. Thus, being at the heart of medically ...
Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates
(MDPI, 2019-06-25)
A fluorine nuclear magnetic resonance (F-19-NMR)-based method is employed to assess the binding preferences and interaction details of a library of synthetic fluorinated monosaccharides towards dendritic cell-specific ...
Glycan structures and their interactions with proteins. A NMR view
(Elsevier, 2019-12)
Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, ...
Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction
(American Chemical Society, 2019-08-28)
The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide (Sp1) is an important anchor point for our immune system to act against streptococcal infections. Antibodies can recognize Sp1 saccharides, and it has ...