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Foreword Special Issue Cell Cycle and Regulation
(MDPI, 2020-02-27)
The process of cell division is critical to the growth and development of an organism. As a fertilized egg develops into a mature organism, tissues undergo cellular renewal or commit to terminal differentiation and leave ...
E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL
(MDPI, 2021-12-28)
Targeted disruption of E2f2 in mice causes T-cell hyperactivation and a disproportionate cell cycle entry upon stimulation. However, E2f2−/− mice do not develop a lymphoproliferative condition. We report that E2f2 plays a ...
Foreword Special Issue Genomic Instability in Tumor Evolution and Therapy Response
(MDPI, 2023-06-07)
From an evolutionary perspective, mutations in the DNA molecule act as a source of genetic variation and thus, are beneficial to the adaptation and survival of the species [...]
Targeting E2F Sensitizes Prostate Cancer Cells to Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity
(MDPI, 2022-10-10)
E2F1/E2F2 expression correlates with malignancy in prostate cancer (PCa), but its functional significance remains unresolved. To define the mechanisms governed by E2F in PCa, we analyzed the contribution of E2F target genes ...
Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells
(BMC, 2021-02-19)
BACKGROUND: The G1 checkpoint is a critical regulator of genomic stability in untransformed cells, preventing cell cycle progression after DNA damage. DNA double-strand breaks (DSBs) recruit and activate ATM, a kinase which ...