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Synthesis of Heterocyclic Fused [1,5]naphthyridines by Intramolecular HDA Reactions
(MDPI, 2019-09-06)
Povarov reaction [1] can be considered as an example of HDA reactions and represents an
excellent method for the preparation of nitrogen-containing heterocyclic compounds [2]. When
aldimines, derived from aromatic amines ...
A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives
(MDPI, 2019-08)
Bronsted acids catalyze a multicomponent reaction of benzaldehyde with amines and diethyl acetylenedicarboxylate to afford highly functionalized gamma-lactam derivatives. The reaction consists of a Mannich reaction of an ...
Design and Evaluation of New Phosphorus Substituted Aziridines as Antiproliferative Agents
(MDPI, 2019-08-09)
Covalent bond formation has become a safe and effective strategy applied not only by nature but also by the pharmaceutical industry to improve disease pharmacology. In the history of modern medicine, covalent drugs have ...