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The Intramolecular Povarov Tool in the Construction of Fused Nitrogen-Containing Heterocycles
(Springer, 2023-06)
Nitrogen heterocycles are part of the structure of natural products and agents with
important biological activity, such as antiviral, antibiotic, and antitumor drugs. For
this reason, heterocyclic compounds are one of ...
Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions
(MDPI, 2023-01-03)
New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against ...
Antileishmanial Effect of 1,5- and 1,8-Substituted Fused Naphthyridines
(MDPI, 2023-12-22)
In the absence of a vaccine, there is a need to find new drugs for the treatment of neglected tropical diseases, such as leishmaniasis, that can overcome the many drawbacks of those currently used. These disadvantages ...