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A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
(Nature Publishing Group, 2019-12)
N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ...
Implication of m6A mRNA Methylation in Susceptibility to Inflammatory Bowel Disease
(MDPI, 2020-08-03)
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that develops due to the interaction between genetic and environmental factors. More than 160 loci have been associated ...
Celiac Diasease-associated lncRNA Named HCG14 Regulates NOD1 Expression in Intestinal Cells
(Wiley, 2018-08-01)
Objective:
The aim of the study is to identify additional celiac disease associated loci in the major histocompatibility complex (MHC) independent from classical HLA risk alleles (HLA-DR3-DQ2) and to characterize their ...
A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells
(Frontiers Media, 2023-02)
IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long ...
m6A Methylated Long Noncoding RNA LOC339803 Regulates Intestinal Inflammatory Response
(Wiley, 2024-04)
Cytokine mediated sustained inflammation increases the risk to develop different complex chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing evidence shows that long noncoding RNAs ...