Show simple item record

Modelling Lipid Competition Dynamics in Heterogeneous Protocell Populations

dc.contributor.authorShirt-Ediss, Benjamin John
dc.contributor.authorRuiz Mirazo, Pedro
dc.contributor.authorMavelli, Fabio
dc.contributor.authorSolé, Ricard V.
dc.date.accessioned2015-12-10T14:36:11Z
dc.date.available2015-12-10T14:36:11Z
dc.date.issued2014-07-14
dc.identifier.citationScientific Reports 4 : (2014) // Article ID 5675es
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10810/16415
dc.description.abstractRecent experimental work in the field of synthetic protocell biology has shown that prebiotic vesicles are able to 'steal' lipids from each other. This phenomenon is driven purely by asymmetries in the physical state or composition of the vesicle membranes, and, when lipid resource is limited, translates directly into competition amongst the vesicles. Such a scenario is interesting from an origins of life perspective because a rudimentary form of cell-level selection emerges. To sharpen intuition about possible mechanisms underlying this behaviour, experimental work must be complemented with theoretical modelling. The aim of this paper is to provide a coarse-grain mathematical model of protocell lipid competition. Our model is capable of reproducing, often quantitatively, results from core experimental papers that reported distinct types vesicle competition. Additionally, we make some predictions untested in the lab, and develop a general numerical method for quickly solving the equilibrium point of a model vesicle population.es
dc.description.sponsorshipR.S. and B.S.-E. acknowledge support from the Botin Foundation and by the Santa Fe Institute. K.R.-M. acknowledges support from the Basque Government (Grant IT 590-13), Spanish Ministry of Science (MINECO Grant FFI2011-25665), COST Action CM 1304 (Emergence and Evolution of Complex Chemical Systems). F.M. acknowledges support from MIUR (PRIN 2010/11 2010BJ23MN_003). We thank Itay Budin and Irene Chen for kindly providing original experimental data for Figure 4, and the Group of Dynamical Systems (Department of Applied Mathematics and Analysis) from Universitat de Barcelona for providing us with the Runge-Kutta-Fehlberg algorithm used for numerical integration of the model.es
dc.language.isoenges
dc.publisherNature Publishing Groupes
dc.relationinfo:eu-repo/grantAgreement/MINECO/FFI2011-25665
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectstochastic simulationses
dc.subjectflip-flopes
dc.subjectvesicleses
dc.subjectacides
dc.subjectreproductiones
dc.subjectmembraneses
dc.subjectsystemses
dc.titleModelling Lipid Competition Dynamics in Heterogeneous Protocell Populationses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holderThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission fromthe license holder in order to reproduce thematerial. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/es
dc.relation.publisherversionhttp://www.nature.com/articles/srep05675#abstractes
dc.identifier.doi10.1038/srep05675
dc.departamentoesLógica y filosofía de la cienciaes_ES
dc.departamentoeuLogika eta zientziaren filosofiaes_ES
dc.subject.categoriaMULTIDISCIPLINARY SCIENCES


Files in this item

Thumbnail
Name:
srep05675.pdf
Size:
2.068Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record