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Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients

dc.contributor.authorQuerido, Jailson F. B.
dc.contributor.authorEcheverría, María G.
dc.contributor.authorMartí, Gerardo A.
dc.contributor.authorMedina Costa, Rita
dc.contributor.authorSusevich, María L.
dc.contributor.authorRabinovich, Jorge E.
dc.contributor.authorCopa, Aydee
dc.contributor.authorMontaño, Nair A.
dc.contributor.authorGarcia, Lineth
dc.contributor.authorCordova, Marisol
dc.contributor.authorTorrico, Faustino
dc.contributor.authorSánchez Eugenia, Rubén ORCID
dc.contributor.authorSánchez Magraner, Lissete
dc.contributor.authorMuñiz Trabudua, Xabier
dc.contributor.authorLópez Marijuan, Ibai
dc.contributor.authorRozas-Dennis, Gabriela S.
dc.contributor.authorDiosque, Patricio
dc.contributor.authorDe Castro, Ana M.
dc.contributor.authorRobello, Carlos
dc.contributor.authorRodríguez, Julio S.
dc.contributor.authorAltcheh, Jaime
dc.contributor.authorSalazar-Schettino, Paz M.
dc.contributor.authorBucio, Marta I.
dc.contributor.authorEspinoza, Bertha
dc.contributor.authorGuérin Silva, Diego M. A.
dc.date.accessioned2016-05-06T13:46:56Z
dc.date.available2016-05-06T13:46:56Z
dc.date.issued2015-01-17
dc.identifier.citationParasites & Vectors 8 : (2015) // Article ID UNSP 29es
dc.identifier.issn1756-3305
dc.identifier.urihttp://hdl.handle.net/10810/18179
dc.description.abstractBackground: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake. Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.es
dc.description.sponsorshipWe thank the Hospital Municipal de Agudos "Dr. L. Lucero", Bahia Blanca, and Hospital de Ninos "R. Gutierrez", Buenos Aires, Argentina, for providing sera for this study. DMAG thanks the technical assistance of Aritz Durana. GAM was partially supported by CONICET (PIP 0007), CICPBA, Agencia Nacional de Promocion Cientifica y Tecnica (PICT No 2008-0035 and PICT 2011-1081), and the National University of La Plata, Argentina. RSE is a recipient of a pre-doctoral fellowship from the Basque Government (BG). LS-M has a JAE-Doc contract from CSIC, Spain. ILM has a doctoral fellowship from the Fundacion Biofisica Bizkaia, Spain. DMAG wants to thank A. Gemio and F. Espejo (Inesfly) and all members of the MOMIN, in Camiri, Bolivia, for their kindness and hospitality during his visit. MSS is a Fellow Capes/Brazil. DMAG was partially supported by BG grants MV-2012-2-41, SPE1 1FB001, MECON BFU2012-36241, and Fundacion Biofisica Bizkaia, Spain. All authors acknowledge the supporting institutions of RedTrV CSIC I-COOP0080 (Spain), BG AE-2009-1-21, Fundacion Biofisica Bizkaia, CYTED (209RT0364), and BG S-PI13UN001.es
dc.language.isoenges
dc.publisherBiomed Centrales
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjecttriatoma viruses
dc.subjectdicistroviridaees
dc.subjecttrypanosoma cruzies
dc.subjecttriatomineses
dc.subjectchagas diseasees
dc.subjectmathematical modeles
dc.subjectbiological controles
dc.subjectpassive viral exposurees
dc.subjectinfestans hemipteraes
dc.subjectreduviidaees
dc.subjecttransmissiones
dc.subjectargentinaes
dc.subjectTRVes
dc.subjectparticleses
dc.titleSeroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patientses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2015 Querido et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise statedes
dc.relation.publisherversionhttp://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-0632-9#Abs1es
dc.identifier.doi10.1186/s13071-015-0632-9
dc.departamentoesBioquímica y biología moleculares_ES
dc.departamentoeuBiokimika eta biologia molekularraes_ES
dc.subject.categoriaINFECTIOUS DISEASES
dc.subject.categoriaPARASITOLOGY


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