BackBrowsing ACHUCARRO by Subject "MEDICINE"
Now showing items 1-8 of 8
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ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP
; ; ; Zugaza Gurruchaga, José Luis
; ; Marino Sánchez, Aida Luisa (Public Library of Science, 2013)
In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished ... -
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels
Ruiz Núñez, Asier; Alberdi Alfonso, Elena María ; (Nature Publishing Group, 2014-04)
Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ... -
Combined Fluorescent-Chromogenic In Situ Hybridization for Identification and Laser Microdissection of Interphase Chromosomes
Paz Gandiaga, Nerea; Zabala, Amaia; Royo, Félix; García-Orad Carles, África; Zugaza Gurruchaga, José Luis ; Parada, Luis A. (Public Library of Science, 2013)
Chromosome territories constitute the most conspicuous feature of nuclear architecture, and they exhibit non-random distribution patterns in the interphase nucleus. We observed that in cell nuclei from humans with Down ... -
Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis
Lutz, Sarah E.; González Fernández, Estibaliz; Chara Ventura, Juan Carlos; Pérez Samartín, Alberto Luis; Tarassishin, Leonid; Negoro, Hiromitsu; Patel, Naman K.; Suadicani, Sylvia O.; Lee, Sunhee C.; ; Scemes, Eliana (Public Library of Science, 2013-06)
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. ... -
Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine
Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; ; Sánchez Gómez, María Victoria; Domercq García, María ; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ... -
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María; (Nature Publishing Group, 2012-02)
We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ... -
PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats
Domercq García, María; Szczupak, Boguslaw; Gejo, Jon; Gómez-Vallejo, Vanessa; Padró, Daniel; Gona, Kiran Babu; Dollé, Frédéric; Higuchi, Makoto; ; Llop Roig, Jordi ; Martín Muñoz, Abraham (2016)
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Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis
; Alberich, Susana; Echeburúa Odriozola, Enrique ; Aizpuru Barandiaran, Felipe ; ; ; ; González Pinto Arrillaga, Ana María (Public Library Science, 2015-04-15)
Background Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ...