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Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
(2018-05-04)
The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has ...
Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
(Biomed Central, 2017-07-24)
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ...
Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
(Hindawi, 2016)
Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ...
Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis
(Public Library Science, 2015-04-15)
Background
Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ...
The role of purinergic receptor A1 in neurogenesis modulation from subventricular zone
(2016-06-16)
La neurogénesis continúa en la edad adulta en regiones específicas del cerebro como la zona subgranular del hipocampo y la zona subventricular (SVZ) de los ventrículos laterales. Resultados previos de nuestro laboratorio ...
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
(Nature Publishing Group, 2012-02)
We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ...
NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation
(Frontiers Research Foundation, 2013-12-18)
Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ...
Papel de las GTPasas de la familia rho en la señalización mediada por el receptor P2X7
(2013-09-24)
El objetivo de este proyecto es estudiar la señalización del receptor P2X7 en respuesta a ATP en macrófagos J774A.1 y en células CHO K1. Para ello, se subclonó el gen que codifica para la proteína P2X7 en el vector PMT2 ...
FTY720 attenuates excitotoxicity and neuroinflammation
(BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...