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Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
Cipriani, Raffaela
; ; ; (Biomed Central, 2017-07-24)
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ... -
Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
(Hindawi, 2016)Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ... -
Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation
(null, 2015)Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 ... -
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome
; Mato Santos, Susana; ; ; ; ; (null, 2016)
Mice heterozygous for a complete deletion (CD) equivalent to the most common deletion found in individuals with Williams-Beuren syndrome (WBS) recapitulate relevant features of the neurocognitive phenotype, such as ...