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dc.contributor.authorCastilla Cortázar, Inmaes
dc.contributor.authorPascual, Maríaes
dc.contributor.authorUrdaneta Artola, Elenaes
dc.contributor.authorPardo, Javieres
dc.contributor.authorPuche, Juan Enriquees
dc.contributor.authorVivas, Bárbaraes
dc.contributor.authorDíaz Casares, Ameliaes
dc.contributor.authorGarcía, Maríaes
dc.contributor.authorDíaz Sánchez, Matíases
dc.contributor.authorVarela Nieto, Isabeles
dc.contributor.authorCastilla Cortazar, Albertoes
dc.contributor.authorGonzález Barón, Salvadores
dc.date.accessioned2010-12-14T11:58:51Zes
dc.date.accessioned2011-03-29T04:50:42Z
dc.date.available2010-12-14T11:58:51Zes
dc.date.available2011-03-29T04:50:42Z
dc.date.issued2004-06-14es
dc.identifier.citationBMC Gastroenterology 4(12) : (2004)es
dc.identifier.issn1471-230Xes
dc.identifier.urihttp://hdl.handle.net/10810/2185es
dc.descriptionEs reproducción del documenteo publicado en http://dx.doi.org/10.1186/1471-230X-4-12es
dc.description.abstractBackground: Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the administration of Insulin-Like Growth Factor-I (IGF-I). The aims of this study were to explore the evolution of these alterations and analyse the effect of IGF-I in rats with advanced cirrhosis and ascites. Thus, jejunal structure and nutrient transport (D-galactose, L-leucine, L-proline, L-glutamic acid and L-cystine) were studied in rats with ascitic cirrhosis. Methods: Advanced cirrhosis was induced by CCl4 inhalation and Phenobarbital administration for 30 weeks. Cirrhotic animals were divided into two groups which received IGF-I or saline during two weeks. Control group was studied in parallel. Jejunal microvilli were studied by electron microscopy. Nutrient transport was assessed in brush border membrane vesicles using C-14 or S-35-labelled subtracts in the three experimental groups. Results: Intestinal active Na+-dependent transport was significantly reduced in untreated cirrhotic rats. Kinetic studies showed a decreased V-max and a reduced affinity for sugar and four amino acids transporters ( expressed as an increased K-t) in the brush border membrane vesicles from untreated cirrhotic rats as compared with controls. Both parameters were normalised in the IGF-I-treated cirrhotic group. Electron microscopy showed elongation and fusion of microvilli with degenerative membrane lesions and/or notable atrophy. Conclusions: The initial microvilli elongation reported in non ascitic cirrhosis develops into atrophy in rats with advanced cirrhosis and nutrient transports (monosaccharides and amino acids) are progressively reduced. Both morphological and functional alterations improved significantly with low doses of IGF-I.es
dc.language.isoenges
dc.publisherBioMed Centrales
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectliver cirrhosises
dc.subjectmalabsorptiones
dc.subjectintestinal atrophyes
dc.subjectIGF-Ies
dc.subjectinsulin like growth factor Ies
dc.subjectundernutritiones
dc.titleJejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor Ies
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder(c) 2004 Castilla-Cortázar et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.es
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES
dc.subject.categoriaGASTROENTEROLOGY AND HEPATOLOGY


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