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dc.contributor.advisorMoujahid, Abdelmalik ORCID
dc.contributor.authorCarreño Muñoz, María Isabel
dc.date.accessioned2018-01-23T09:56:25Z
dc.date.available2018-01-23T09:56:25Z
dc.date.issued2017-09-22
dc.date.submitted2017-09-22
dc.identifier.urihttp://hdl.handle.net/10810/24667
dc.description155 p.es_ES
dc.description.abstractModern neuroscience highlights the need for designing sophisticated behavioral readout of internal cognitive states. From a thorough analysis of classical behavioral test, my results supports the hypothesis that sensory ypersensitivity might be the cause of other behavioural deficits, and confirm the potassium channel BKCa as a potentially relevant molecular target for the development of drug medication against Fragile X Syndrome/Autism Spectrum Disorders. I have also used an innovative device, based on pressure sensors that can non-invasively detect the slightest animal movement with unprecedented sensitivity and time resolution, during spontaneous behaviour. Analysing this signal with sophisticated computational tools, I could demonstrate the outstanding potential of this methodology for behavioural phenotyping in general, and more specifically for the investigation of pain, fear or locomotion in normal mice and models of neurodevelopmental and neurodegenerative disorders.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectenfermedades_ES
dc.titleSupervised and unsupervised investigation of the temporal dynamics of normal and pathological behaviour in the mouse and rat
dc.title.alternativeEstudio Experimental de las dinámicas temporales del comportamiento normal y patológico en ratón y rata.
dc.title.alternativeEtude expérimentale des dynamiques temporelles du comportement normal et pathologique chez le rat et la souris
dc.typeinfo:eu-repo/semantics/doctoralThesises_ES
dc.rights.holder(c)2017 MARIA ISABEL CARREÑO MUÑOZ
dc.identifier.studentID562759es_ES
dc.identifier.projectID16165es_ES
dc.departamentoesCiencia de la computación e inteligencia artificiales_ES
dc.departamentoeuKonputazio zientziak eta adimen artifizialaes_ES


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