BackBrowsing Artículos by Author "COSSIO MORA, FERNANDO PEDRO"
Now showing items 1-18 of 18
-
Additive and Emergent Catalytic Properties of Dimeric Unnatural Amino Acid Derivatives: Aldol and Conjugate Additions.
; ; ; ; ; Cossío Mora, Fernando Pedro
(Wiley, 2021-11-11)
[EN]Different densely substituted L- and D-proline esters were prepared by asymmetric (3+2) cycloaddition reactions catalyzed by conveniently selected EhuPhos chiral ligands. The gamma-nitro-2-alkoxycarbonyl pyrrolidines ... -
Application of 1,3-Dipolar Reactions between Azomethine Ylides and Alkenes to the Synthesis of Catalysts and Biologically Active Compounds
; Arrieta Ayestaran, Ana Jesús; Cossío Mora, Fernando Pedro (Wiley, 2018-11-25)
The (3+2) cycloaddition between azomethine ylides and alkenes is an efficient, convergent and stereocontrolled method for the synthesis of unnatural pyrrolidine and proline scaffolds. In this review, the application of ... -
Aromaticity: Quo Vadis
; ; ; ; ; ; ; ; Cossío Mora, Fernando Pedro; ; ; ; (Royal Society of Chemistry, 2023)
Aromaticity is one of the most deeply rooted concepts in chemistry. But why, if two-thirds of existing compounds can be classified as aromatic, is there no consensus on what aromaticity is? s−, p−, d−, spherical, Möbius, ... -
Ba+2 ion trapping using organic submonolayer for ultra-low background neutrinoless double beta detector
; Cossío Mora, Fernando Pedro; (Nature, 2022-12)
If neutrinos are their own antiparticles the otherwise-forbidden nuclear reaction known as neutrinoless double beta decay can occur. The very long lifetime expected for these exceptional events makes its detection a daunting ... -
Bicolour fluorescent molecular sensor for cations: design and experimental validation
; Rivilla de la Cruz, Iván; ; ; Cossío Mora, Fernando Pedro (Royal Society of Chemistry, 2021-07-02)
Molecular entities whose fluorescence spectra are different when they bind metal cations are termed bicolour fluorescent molecular sensors. The basic design criteria of this kind of compound are presented and the different ... -
Boosting background suppression in the NEXT experiment through Richardson-Lucy deconvolution
The NEXT collaboration; Almazán, H.; Aparicio Gil, Borja; Aranburu Leiva, Ane Izaskun; Benlloch-Rodríguez, J.M.; Cossío Mora, Fernando Pedro; Ferrario, P.; Generowicz, J.; Gómez Cadenas, Juan J.; Herrero, P.; Martínez-Vara, M.; Monrabal, Francesc; Oblak, E.; Odriozola Gimeno, Mikel; Ripoll, L.; Rivilla de la Cruz, Iván ; Rogero Blanco, Celia; Romeo, B.; Romo-Luque, C.; Santos, F.P.; Dos Santos, J.M.F.; Sorel, M.; Stanford, C.; Teixeira, J.M.R.; Thapa, P.; Toledo, J.F.; Torrent, J.; Usón, A.; Veloso, J.F.C.A.; Vuong, T.T.; Webb, R.; White, J.T.; Woodruff, K.; Yahlali, N. (Springer, 2021-07-21)
Next-generation neutrinoless double beta decay experiments aim for half-life sensitivities of similar to 10(27) yr, requiring suppressing backgrounds to < 1 count/tonne/yr. For this, any extra background rejection handle, ... -
Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(II) and copper(II) complex
Rivilla de la Cruz, Iván; ; Schäfer, Thomas ; ; ; ; Aboudzadeh, Ali ; ; ; Cossío Mora, Fernando Pedro (Royal Society of Chemistry, 2017-08-11)
A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides. The catalytic system is based on the distortion of the double ... -
Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor
Martín Rodríguez, María; Nájera, Carmen; Sansano, José M.; De Cózar Ruano, Abel; Cossío Mora, Fernando Pedro (Beilstein Institut, 2011-07)
The synthesis of a GSK 2(nd) generation inhibitor of the hepatitis C virus, by enantioselective 1,3-dipolar cycloaddition between a leucine derived iminoester and tert-butyl acrylate, was studied. The comparison between ... -
Dehydration of alcohols catalyzed by copper(ii) sulfate: type II dyotropic reactions and stepwise mechanisms
; ; ; ; ; Cossío Mora, Fernando Pedro (RSC, 2024)
Dehydration of alcohols in the presence of copper(II) sulfate has been analyzed computationally. Density functional theory (DFT) calculations on selected alcohols indicate that this reaction can take place via two possible ... -
Enantioselective Ring-Opening Polymerization of rac-Lactide Dictated by Densely Substituted Aminoacids
; Rivilla de la Cruz, Iván; ; ; Etxeberria Lizarraga, Agustín ; ; ; ; Cossío Mora, Fernando Pedro (ACS, 2017-03-08)
Organocatalysis is becoming an important tool in polymer science because of its versatility and specificity. To date a limited number of organic catalysts have demonstrated the ability to promote stereocontrolled ... -
Fluorescent bicolour sensor for low-background neutrinoless double β decay experiments
Rivilla de la Cruz, Iván; ; ; ; ; ; ; ; ; ; ; ; Schäfer, Thomas ; ; ; Cossío Mora, Fernando Pedro ; Gómez Cadenas, Juan J. (Nature, 2020-06-22)
Observation of the neutrinoless double β decay is the only practical way to establish that neutrinos are their own antiparticles1. Because of the small masses of neutrinos, the lifetime of neutrinoless double β decay is ... -
Higher-Order Electrocyclizations in Biological and Synthetic Processes
; ; ; Cossío Mora, Fernando Pedro (Wiley, 2023-11)
In general, electrocyclizations follow the Woodward-Hoffmann's rules of conservation of orbital symmetry. These rules have been extensively verified in low-order processes, both in thermal and photochemical reactions, up ... -
Lacking Immunotherapy Biomarkers for Biliary Tract Cancer: A Comprehensive Systematic Literature Review and Meta-Analysis
; Cossío Mora, Fernando Pedro; Bañales Asurmendi, Jesús María ; ; ; ; (MDPI, 2023-08-19)
Background: Immunotherapy has recently been incorporated into the spectrum of biliary tract cancer (BTC) treatment. The identification of predictive response biomarkers is essential in order to identify those patients who ... -
Phenanthrene-Extended Phenazine Dication: An Electrochromic Conformational Switch Presenting Dual Reactivity
; ; ; Cossío Mora, Fernando Pedro; (American Chemical Society, 2022)
The synthesis and isolation of one of the few examples of a pi-extended diamagnetic phenazine dication have been achieved by oxidizing a phenanthrene-based dihydrophenazine precursor. The resulting dication was isolated ... -
Synthesis of Bicyclic Hemiacetals Catalyzed by Unnatural Densely Substituted gamma-Dipeptides
; ; ; ; Cossío Mora, Fernando Pedro (American Chemical Society, 2022-09)
The asymmetric synthesis of bicyclic highly substituted tetrahydropyrans is described. The reaction is catalyzed by unnatural γ-dipeptides based on densely substituted l- and d-proline derivatives. This organocatalytic ... -
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
Caballero Camino, Francisco Javier; Rivilla de la Cruz, Iván ; Herráez Aguilar, Elisa; Briz Sánchez, Oscar; Santos Laso, Álvaro; ; ; Rodrigues, Pedro M.; Muñoz Garrido, Patricia; Jin, Sujeong; Peixoto, Estanislao; Richard, Seth; Gradilone, Sergio A.; Perugorria Montiel, María Jesús; Esteller, Manel; Bujanda Fernández de Pierola, Luis ; Marin, José J. G.; Bañales Asurmendi, Jesús María ; Cossío Mora, Fernando Pedro (Wiley, 2020-09-22)
Background and Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of symptomatic biliary cysts. Current surgical and pharmacological approaches are ineffective, and liver ... -
Synthetic scope and DFT analysis of the chiral binap-gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes
Martín Rodríguez, María; Castelló, Luis M.; Nájera, Carmen; Sansano, José M.; Larrañaga Agirre, Olatz; De Cózar Ruano, Abel; Cossío Mora, Fernando Pedro (Beilstein Institut, 2013-11)
he 1,3-dipolar cycloaddition between glycine-derived azlactones with maleimides is efficiently catalyzed by the dimeric chiral complex [(S-a)-Binap.AuTFA](2). The alanine-derived oxazolone only reacts with tert-butyl ... -
Towards a more precise therapy in cancer: Exploring epigenetic complexity
Cossío Mora, Fernando Pedro; Esteller, Manel; Berdasco, María (Elsevier, 2020-08)
A plethora of preclinical evidences suggests that pharmacological targeting of epigenetic dysregulation is a potent strategy to combat human diseases. Nevertheless, the implementation of epidrugs in clinical practice is ...