BackBrowsing Artículos by Subject "CELLULAR AND MOLECULAR NEUROSCIENCE"
Now showing items 21-33 of 33
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Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes
Ruiz Núñez, Asier
; ; Alberdi Alfonso, Elena María (Nature Publishing Group, 2010-07)
Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause ... -
Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord
(BioMed Central, 2011-10-10)Background: The adult central nervous system (CNS) contains different populations of immature cells that could possibly be used to repair brain and spinal cord lesions. The diversity and the properties of these cells in ... -
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
(Frontiers Research Foundation, 2013-01)Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored ... -
Metabolic efficiency with fast spiking in the squid axon
Moujahid, Abdelmalik; D'Anjou, Alicia (Frontiers, 2012-11-15)
Fundamentally, action potentials in the squid axon are consequence of the entrance of sodium ions during the depolarization of the rising phase of the spike mediated by the outflow of potassium ions during the hyperpolarization ... -
Neurotransmitter signaling in the pathophysiology of microglia
Domercq García, María; Vázquez Villoldo, Nuria; (Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ... -
Never-resting microglia: physiological roles in the healthy brain and pathological implications
(Frontiers Research Foundation, 2014-08-15)Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a ... -
NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation
(Frontiers Research Foundation, 2013-12-18)Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ... -
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María; (Nature Publishing Group, 2012-02)
We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ... -
Physiological modules for generating discrete and rhythmic movements: action identification by a dynamic recurrent neural network
(Frontiers Research Foundation, 2014-09-17)In this study we employed a dynamic recurrent neural network (DRNN) in a novel fashion to reveal characteristics of control modules underlying the generation of muscle activations when drawing figures with the outstretched ... -
Physiological modules for generating discrete and rhythmic movements: Component analysis of EMG signals
(Frontiers Research Foundation, 2015-01-09)A central question in Neuroscience is that of how the nervous system generates the spatiotemporal commands needed to realize complex gestures, such as handwriting. A key postulate is that the central nervous system (CNS) ... -
Pio del Rio Hortega and the discovery of the oligodendrocytes
Pérez Cerdá, Fernando; Sánchez Gómez, María Victoria ; (Frontiers Research Foundation, 2015-07-07)
Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ... -
Spinal circuits can accommodate interaction torques during multijoint limb movements
(Frontiers Research Foundation, 2014-11-11)The dynamic interaction of limb segments during movements that involve multiple joints creates torques in one joint due to motion about another. Evidence shows that such interaction torques are taken into account during ... -
The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers
Fernández Martínez, Manuel; Elcoroaristizabal Martín, Xabier; Galdos Alcelay, Luis; Castro Flores, Jessica; Uterga Valiente, Juan MarÍa; Indakoetxea Juanbeltz, Begoña; Gómez Beldarrain, María Angeles; Moraza López, Josefa; González Fernández, María Carmen; Molano Salazar, Ana; Bereincua Gandarias, Rocío; Inglés Borda, Sandra; Ortiz Marqués, Nuria; Barandiaran Amillano, Miryam; Carrasco Zabaleta, María; Martínez de Pancorbo Gómez, María de los Angeles (BioMed Central, 2009-09)
Background: The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (polymorphism Val158 Met) as a risk factor for Alzheimer's disease (AD) and mild cognitive impairment of amnesic ...