Examinar Artículos por departamento (cas.) "Química orgánica I"
Now showing items 41-60 of 154
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Dehydration of alcohols catalyzed by copper(ii) sulfate: type II dyotropic reactions and stepwise mechanisms
(RSC, 2024)Dehydration of alcohols in the presence of copper(II) sulfate has been analyzed computationally. Density functional theory (DFT) calculations on selected alcohols indicate that this reaction can take place via two possible ... -
Design and Evaluation of New Phosphorus Substituted Aziridines as Antiproliferative Agents
(MDPI, 2019-08-09)Covalent bond formation has become a safe and effective strategy applied not only by nature but also by the pharmaceutical industry to improve disease pharmacology. In the history of modern medicine, covalent drugs have ... -
Design and synthesis of quasi-diastereomeric molecules with unchanging central, regenerating axial and switchable helical chirality via cleavage and formation of Ni(II)–O and Ni(II)–N coordination bonds
(Beilstein Institut, 2012-11-13)We describe herein the design and synthesis of asymmetric, pentadentate ligands, which are able to coordinate to Ni(II) cations leading to quasi-diastereomeric complexes displaying two new elements of chirality: stereogenic ... -
Design, synthesis and cytotoxic evaluation of diphenyl(quinolin-8-yl)phosphine oxides
(Elsevier, 2021-04)A new strategy is reported for the synthesis of quinolinylphosphine oxides via the Povarov reaction between phosphorous aldimines and acetylenes. Moreover, these compounds were studied for in vitro cytotoxicity on a human ... -
Detrifluoroacetylative in Situ Generated Cyclic Fluorinated Enolatesfor the Preparation of Compounds Featuring a C−F StereogenicCenter
(American Chemical Society, 2019-11-26)Practical methods for the preparation of selectively fluorinated compounds are in extremely high demand in nearly every sector of the pharmaceutical and agrochemical industries. Here we provided an account of the recent ... -
Development of an α’-hydroxy enone for the aminocatalytic asymmetric formal conjugate addition of aldehydes to acrylates, vinyl ketones and acrolein
(Royal Society of Chemistry, 2023-05-24)Aminocatalytic asymmetric conjugate addition of aldehydes to Michael acceptors is a well established C–C bond forming methodology. However, various acrylic-type acceptors, including acrylic acid derivatives and acrolein, ... -
Development of Hamari Ligands for Practical Asymmetric Synthesisof Tailor-Made Amino Acids
(American Chemical Society, 2019-11-19)Enantiomerically pure tailor-made amino acids are in extremely high demand in nearly every sector of the health-related industries. In particular, the rapidly growing number of amino-acid-based pharmaceuticals calls for ... -
Diastereoselective ZnCl2-Mediated Joullié–Ugi Three-Component Reaction for the Preparation of Phosphorylated N-Acylaziridines from 2H-Azirines
(MDPI, 2024-02-27)We disclose a direct approach to the diastereoselective synthesis of phosphorus substituted N-acylaziridines based on a one-pot ZnCl2-catalyzed Joullié–Ugi three-component reaction of phosphorylated 2H-azirines, carboxylic ... -
Diethyl(benzamido(diisopropoxyphosphoryl)methyl) phosphonate
(MDPI, 2022-08-11)Bisphosphonates are widely used in medicine and related areas, mainly for the treatment of bone diseases, such as osteoporosis. However, their synthesis is usually performed under harsh reaction conditions. In order to ... -
DoE-driven development of an organocatalytic enantioselective addition of acetaldehyde to nitrostyrenes in water
(Wiley-VCH, 2022-03-01)Moving from organic solvents to water is not always an easy task, especially when a lot of variables need to be screened. The development of an enantioselective enamine-catalysed Michael addition of acetaldehyde to ... -
Dynamic Nucleophilic Aromatic Substitution of Tetrazines
(Wiley, 2021-08-23)A dynamic nucleophilic aromatic substitution of tetrazines (SNTz) is presented herein. It combines all the advantages of dynamic covalent chemistry with the versatility of the tetrazine moiety. Indeed, libraries of compounds ... -
Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions
(MDPI, 2023-01-03)New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against ... -
Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Bronsted Base/H-Bonding Catalysis
(Wiley, 2019-03-21)Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Brønsted base/H-bond catalysts ... -
Enantioselective Construction of Tetrasubstituted Stereogenic Carbons through Brønsted Base Catalyzed Michael Reactions: α´-Hydroxy Enones as Key Enoate Equivalent
(ACS, 2014-11-25)Catalytic and asymmetric Michael reactions constitute very powerful tools for the construction of new C–C bonds in synthesis, but most of the reports claiming high selectivity are limited to some specific combinations of ... -
Enantioselective Michael Addition of Aldehydes to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide
(MDPI, 2018-12-12)A primary amine-salicylamide derived from chiral trans-cyclohexane-1,2-diamine was used as an organocatalyst for the enantioselective conjugate addition of aldehydes, mainly ,-disubstituted to N-substituted maleimides. The ... -
Enhancing Dual-State Emission in Maleimide Fluorophores through Fluorocarbon Functionalisation
(Wiley, 2022-10)Herein, a library of trifluoroethyl substituted aminomaleimide derivatives are reported with small size and enhanced emissions in both solution and solid-state. A diCH2CF3 substituted aminochloromaleimide exhibits the most ... -
Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments
(American Chemical Society, 2022-09-08)Development of small molecules targeting the PD-L1/PD-1 interface is advancing both in industry and academia, but only a few have reached early-stage clinical trials. Here, we take a closer look at the general druggability ... -
Exploring the Synthetic Potential of γ-Lactam Derivatives Obtained from a Multicomponent Reaction—Applications as Antiproliferative Agents
(MDPI, 2022)[EN] A study on the reactivity of 3-amino α,β-unsaturated γ-lactam derivatives obtained from a multicomponent reaction is presented. Key features of the substrates are the presence of an endocyclic α,β-unsaturated amide ... -
Extended Enolates: Versatile Intermediates for Asymmetric C-H Functionalization via Noncovalent Catalysis
(Wiley, 2021)Catalyst-controlled functionalization of unmodified carbonyl compounds is a relevant operation in organic synthesis, especially when high levels of site- and stereo-selectivity can be attained. This objective is now within ... -
Featured Reviews in Organic Chemistry
(MDPI, 2023-08-09)The field of Organic Chemistry represents one of the most traditional areas of chemistry that has delivered many benefits to the community of chemists. This Special Issue of Molecules is a compilation of the most recent ...