BackExaminar Artículos por departamento (cas.) "Química orgánica I"
Now showing items 61-80 of 154
-
Fluorescent bicolour sensor for low-background neutrinoless double β decay experiments
Rivilla de la Cruz, Iván
; ; ; ; ; ; ; ; ; ; ; ; Schäfer, Thomas ; ; ; Cossío Mora, Fernando Pedro ; Gómez Cadenas, Juan J. (Nature, 2020-06-22)
Observation of the neutrinoless double β decay is the only practical way to establish that neutrinos are their own antiparticles1. Because of the small masses of neutrinos, the lifetime of neutrinoless double β decay is ... -
Flurbiprofen: A Study of the Behavior of the Scalemate by Chromatography, Sublimation, and NMR
Kwiatkowska, Magdalena; Wzorek, Alicja; Kolbus, Anna; Urbaniak, Mariusz; Han, Jianlin; Soloshonok, Vadym Anatolievch ; Klika, Karel D. (MDPI, 2021-03-26)
2-(2-Fluoro-4-biphenyl) propionic acid (flurbiprofen), from the phenylalkanoic acid family of nonsteroidal anti-inflammatory drugs (NSAID’s), is currently on the pharmaceutical market as a racemate. This racemic compound ... -
Four-Step Synthesis of (−)-4-epi-Presilphiperfolan-8α-ol by Intramolecular Iron Hydride Atom Transfer-Mediated Ketone-Alkene Coupling and Studies to Access trans-Hydrindanols with a Botryane Scaffold
(Wiley, 2023-03)From an (R)-(+)-pulegone-derived building block that incorporates the stereo-defined tertiary carbon bearing a methyl group, as found in the targeted sesquiterpenoid, a four-step synthesis of (−)-4-epi-presilphiperfolan-8-α-ol ... -
Fused 1,5-Naphthyridines: Synthetic Tools and Applications
; Fuertes Sánchez, María; ; ; Rubiales Alcaine, María Gloria ; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (MDPI, 2020-07-31)
Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in the fields of synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them ... -
Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds
; ; ; ; ; ; ; ; ; ; Alonso Pérez, Concepción Estibaliz; ; (MDPI, 2023-04-27)
With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary. Among these biomarkers are DNA ... -
Higher-Order Electrocyclizations in Biological and Synthetic Processes
; ; ; Cossío Mora, Fernando Pedro (Wiley, 2023-11)
In general, electrocyclizations follow the Woodward-Hoffmann's rules of conservation of orbital symmetry. These rules have been extensively verified in low-order processes, both in thermal and photochemical reactions, up ... -
Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B)
Selas Lanseros, Asier; Fuertes Sánchez, María; Melcón-Fernández, Estela; Pérez-Pertejo, Yolanda; Reguera, Rosa M.; Balaña-Fouce, Rafael; Knudsen, Birgitta Ruth; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (MDPI, 2021-08-09)
This work describes, for the first time, the synthesis of dialkyl (2-arylquinolin-8-yl)phosphonate derivatives. The preparation was carried out through a direct and simple process as a multicomponent Povarov reaction of ... -
Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
Perretti, Marcelle D.; Pérez Pérez, Yaiza; Soler Carracedo, Kevin; Martín Encinas, Endika; Alonso Pérez, Concepción Estibaliz; Scoccia, Jimena; Carrillo Fumero, Romen (Royal Society of Chemistry, 2022)
[EN] Dynamic nucleophilic aromatic substitution of tetrazines (S(N)Tz) has been employed to build theranostic prodrugs that are activated by hydrogen sulfide. H2S is typically found in high concentrations in some kinds of ... -
Ionic Liquids and Cellulose: Dissolution, Chemical Modification and Preparation of New Cellulosic Materials
Isik, Mehmet; ; (MDPI, 2014-07)
Due to its abundance and a wide range of beneficial physical and chemical properties, cellulose has become very popular in order to produce materials for various applications. This review summarizes the recent advances in ... -
Iron-Catalyzed C(sp3)−H Functionalization of N,N-Dimethylanilines with Isocyanides
Guerrero Azurmendi, Itziar; San Segundo Eizaguirre, Marcos; Correa Navarro, Arkaitz (Royal Society of Chemistry, 2018-01-22)
An efficient ligand-free Fe-catalyzed oxidative Ugi-type reaction toward the assembly of α-amino amides and short peptides is described. The reaction proceeds through the α-C(sp3)−H oxidation of N,N-dimethylanilines and ... -
Iron-Catalyzed Direct α-Arylation of Ethers with Azoles
Correa Navarro, Arkaitz; ; (Royal Society of Chemistry, 2015-07-14)
The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient ... -
Kitamura Electrophilic Fluorination Using HF as a Source of Fluorine
Han, Jianlin; Butler, Greg; Moriwaki, Hiroki; Konno, Hiroyuki; Soloshonok, Vadym Anatolievch ; Kitamura, Tsugio (MDPI, 2020-04-30)
This review article focused on the innovative procedure for electrophilic fluorination using HF and in situ generation of the required electrophilic species derived from hypervalent iodine compounds. The areas of synthetic ... -
Lacking Immunotherapy Biomarkers for Biliary Tract Cancer: A Comprehensive Systematic Literature Review and Meta-Analysis
; Cossío Mora, Fernando Pedro; Bañales Asurmendi, Jesús María ; ; ; ; (MDPI, 2023-08-19)
Background: Immunotherapy has recently been incorporated into the spectrum of biliary tract cancer (BTC) treatment. The identification of predictive response biomarkers is essential in order to identify those patients who ... -
Late-Stage C-H Acylation of Tyrosine-Containing Oligopeptides with Alcohols
; Andrade Sampedro, Paula; Correa Navarro, Arkaitz (American Chemical Society, 2021-09-17)
The selective tagging of amino acids within a peptide framework while using atom-economical C-H counterparts poses an unmet challenge within peptide chemistry. Herein, we report a novel Pd-catalyzed late-stage C-H acylation ... -
Manganese-Catalyzed Multicomponent Synthesis of Tetrasubstituted Propargylamines: System Development and Theoretical Study
(Wiley-VCH, 2020-07-20)The importance of multicomponent reactions as an efficient tool in organic synthesis is widely recognized, as the need for sustainable, practical, atom- and step-economic methodologies is becoming a crucial concept in ... -
Manipulating the fluorescence lifetime at the sub-cellular scale via photo-switchable barcoding
(Nature, 2020-05-18)Fluorescent barcoding is a pivotal technique for the investigation of the microscale world, from information storage to the monitoring of dynamic biochemical processes. Using fluorescence lifetime as the readout modality ... -
Mechanistic studies of the palladium-catalyzed S,O-ligand promoted C–H olefination of aromatic compounds
(Royal Society of Chemistry, 2023-03)Pd-catalyzed C–H functionalization reactions of non-directed substrates have recently emerged as an attractive alternative to the use of directing groups. Key to the success of these transformations has been the discovery ... -
Metal-Catalyzed C(sp2)−H Functionalization Processes of Phenylalanine- and Tyrosine-Containing Peptides
Correa Navarro, Arkaitz (Wiley, 2021-08-06)
The site-selective chemical diversification of biomolecules constitutes an unmet challenge of capital importance within medicinal chemistry and chemical biology. The functionalization of otherwise unreactive C-H bonds holds ... -
Metal-catalyzed C–H functionalization processes upon “click”-triazole assistance
Guerrero Azurmendi, Itziar; Correa Navarro, Arkaitz (Wiley, 2018-08-24)
The functionalization of otherwise unreactive C–H bonds holds great promise for reducing the reliance on existing functional groups while improving energy efficiency and atom-economy. One of the most powerful strategies ... -
Modeling Antibacterial Activity with Machine Learning and Fusion of Chemical Structure Information with Microorganism Metabolic Networks
(American Chemical Society, 2019-02-25)Predicting the activity of new chemical compounds over pathogenic microorganisms with different metabolic reaction networks (MRNs) is an important goal due to the different susceptibility to antibiotics. The ChEMBL database ...