Examinar Artículos por departamento (eus.) "Farmakologia"
Now showing items 81-100 of 130
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Microglial Phagocytosis Dysfunction in the Dentate Gyrus is Related to Local Neuronal Activity in a Genetic Model of Epilepsy
(Wiley, 2020-11)Objective Microglial phagocytosis of apoptotic cells is an essential component of the brain regenerative response during neurodegeneration. Whereas it is very efficient in physiological conditions, it is impaired in mouse ... -
Mitochondrial Metabolism in Major Depressive Disorder: From Early Diagnosis to Emerging Treatment Options
(MDPI, 2024-03-17)Major Depressive Disorder (MDD) is one of the most disabling diseases in the world. MDD is traditionally diagnosed based on a patient’s symptoms, which can lead to misdiagnosis. Although the pathogenic mechanisms of MDD ... -
Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer’s Disease
(MDPI, 2021-11-12)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in aging populations. Recently, the regulation of neurolipid-mediated signaling and cerebral lipid species was shown ... -
Neuroanatomical characterization of the G protein-coupled receptor activity evoked by galanin-related ligands
(Elsevier, 2023-03)Galanin neuropeptide is distributed throughout the mammalian nervous system modulating a plethora of diverse physiological functions, including nociception, cognition and neuroendocrine regulation. The regulation of the ... -
Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
(MDPI, 2023-10-25)Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative ... -
Neuromarketina: kontsumitzaileon garunaren barruan
(Elhuyar, 2012-05-01)Zer nahiago duzu? Pepsi ala Coca-Cola? McDonald´s ala Burger King? Apple ala Microsoft? Mercedes ala Golf? Pentsatu al duzu inoiz norberaren gogoak eta nahiak zertan oinarrituta dauden? Zerk bultzatzen gaitu hori erostera? ... -
Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome
(MDPI, 2024-01-08)Extracellular vesicles (EVs) are tiny membranous structures that mediate intercellular communication. The role(s) of these vesicles have been widely investigated in the context of neurological diseases; however, their ... -
Non-Adherence in Adult Male Patients with Community-Acquired Pneumonia: Relative Forgiveness of Amoxicillin versus Respiratory Fluoroquinolones
(MDPI, 2023-05-01)The consequences of non-adherence to treatment (NAT) on antimicrobial efficacy may depend on drug forgiveness—a property that should account for pharmacokinetics (PK) and pharmacodynamics (PD) as well as interindividual ... -
NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
(MDPI, 2022)Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. ... -
Opposite Alterations of 5¬HT2A Receptor Brain Density in Subjects with Schizophrenia: Relevance of Radiotracers Pharmacological Profile
(Springer, 2021-05-20)The status of serotonin 5HT2A receptors (5HT2ARs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about ... -
Oral and Palmitate Paliperidone Long-Acting Injectable Formulations’ Use in Schizophrenia Spectrum Disorders: A Retrospective Cohort Study from the First Episode Psychosis Intervention Program (CRUPEP)
(Oxford University Press, 2021)Background: Long-acting injectable antipsychotics (LAIs) may be a suitable therapeutic option for those patients in earlier stages of psychosis to avoid relapses and disease progression. Despite that, there is a lack of ... -
Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
(Frontiers Media, 2021-05-13)Emerging evidence indicates that early-life exposure to environmental factors may increase the risk for schizophrenia via inflammatory mechanisms. Inflammation can alter the metabolism of tryptophan through the oxidative ... -
Permissive epigenetic regulatory mechanisms at the histone level are enhanced in postmortem dorsolateral prefrontal cortex of individuals with schizophrenia
(Canadian College of Neuropsychopharmacology, 2024-02)Background: Susceptibility to schizophrenia is determined by interactions between genes and environment, possibly via epigenetic mechanisms. Schizophrenia has been associated with a restrictive epigenome, and histone ... -
Pharmacological Ablation of Astrocytes Reduces Aβ Degradation and Synaptic Connectivity in an Ex Vivo Model of Alzheimer’s Disease
(Springer, 2021-03-17)BackgroundAstrocytes provide a vital support to neurons in normal and pathological conditions. In Alzheimer's disease (AD) brains, reactive astrocytes have been found surrounding amyloid plaques, forming an astrocytic scar. ... -
Pimavanserin exhibits serotonin 5-HT 2A receptor inverse agonism for G αi1 - and neutral antagonism for G αq/11 -proteins in human brain cortex
(Elsevier, 2020-06-07)[EN] Pimavanserin is claimed as the first antipsychotic drug that shows selectivity for serotonin 5- HT 2 receptors (5-HT 2 Rs) and lacks of affinity for dopamine D 2 receptors (D 2 Rs). Cell-based func- tional assays ... -
Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex
(Public Library Science, 2014-01-28)Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, ... -
PK/PD modeling and simulation of the in vitro activity of the combinations of isavuconazole with echinocandins against Candida auris
(Wiley, 2023-06)In vitro combination of echinocandins and isavuconazole against the emerging species Candida auris is mainly synergistic. However, this combination has not been evaluated in clinical settings. A pharmacokinetic/pharmacodynamic ... -
Plasma and serum alpha-synuclein as a biomarker in Parkinson's disease: A meta-analysis
(Elsevier, 2022-06)Background Reliable biomarkers for Parkinson's disease (PD) diagnosis are urgently needed. Alpha-synuclein (α-syn) and its proteoforms play a key role in PD pathology but in vivo measurements have raised conflicting ... -
Plastikotasun neuronala: garunaren zaindari
(Elhuyar, 2011-04-01)Denbora luzez pentsatu da garuneko lesio baten ondorioz neuronak betirako galtzen zirela eta, heldutasunera behin helduta, burmuinaren garapena eten egiten zela. Azken hamarkadetan, berriz, argi geratu da garunak malgutasuna ... -
Plazeraren oinarri neurobiologikoak: sari-sistema zerebrala
(Elhuyar, 2013-07-01)Sari-sistema edo bide mesokortikolinbiko dopaminergiko deritzana plazerarekin erlazionatuta dagoen sare neuronal bat da.Sistema horren aurkikuntza oso garrantzitsua izan da neurozientzia eta psikologia arloan. Lehen ...