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Now showing items 2849-2868 of 10187
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Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61) levels
; ; Azkona Mendoza, Garikoitz
; ; ; ; ; ; (Wiley, 2015-08-28)
Brain-derived neurotrophic factor (BDNF) regulates synaptic strengthening and memory consolidation, and altered BDNF expression is implicated in a number of neuropsychiatric and neurodegenerative disorders. BDNF potentiates ... -
Downscaling of surface moisture flux and precipitation in the Ebro Valley (Spain) using analogues and analogues followed by random forests and multiple linear regression
; Sáenz Aguirre, Jon; ; Elías Saenz, Ana Josefina ; Díaz de Argandoña González, Javier (Copernicus Gesellschaft, 2011)
In this paper, reanalysis fields from the ECMWF have been statistically downscaled to predict from large-scale atmospheric fields, surface moisture flux and daily precipitation at two observatories (Zaragoza and Tortosa, ... -
Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation
Halim, Vincentius A.; García Santisteban, Iraia; Warmerdam, Daniel O; Van den Broek, Bram; Heck, Albert J. R.; Mohammed, Shabaz; Medema, René H. (American Society for Biochemistry and Molecular Biology, 2018-12)
Protein posttranslational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signaling cascade that coordinates ... -
Dragon Ball on the Basque public TV: influence on viewers’ language attitudes and practices
(Taylor & Francis, 2021-07-01)Dragon Ball was highly popular among different generations in the Basque Country. The anime TV series was broadcast in Galician, Catalan and Basque practically at the same time in 1990. The translation and dubbing into ... -
Drilling Process in γ-TiAl Intermetallic Alloys
Beranoagirre Imaz, Aitor; Urbicain Pelayo, Gorka; ; (MDPI, 2018-11-26)
Gamma titanium aluminides (gamma-TiAl) present an excellent behavior under high temperature conditions, being a feasible alternative to nickel-based superalloy components in the aeroengine sector. However, considered as a ... -
Drivers of exploitative and explorative innovation in a collaborative public- sector context
; Etxebarria Miguel, María Carmen (Taylor & Francis, 2019)
This paper studies multilevel networks, in which municipalities collaborate with higher tiers of government (upward collaboration), with peers (outward) and with local stakeholders (inward) to discover innovative ways to ... -
Driving Flows in Microfluidic Paper-Based Analytical Devices with a Cholinium Based Poly Ionic Liquid Hydrogel
Akyazi, Tugce; Tudor, Aleksandru; Diamond, Dermot; Florea, Larisa; Basabe Desmonts, Lourdes; Benito López, Fernando (Elsevier, 2018-01-31)
Paper microfluidics technology requires effective handling and control of fluids, and this remains as asignificant obstacle for their accessibility by end-users, inhibiting their transition from the laboratory intothe ... -
Driving-Style Assessment from a Motion Sickness Perspective Based on Machine Learning Techniques
; Asua Uriarte, Estibaliz; Del Campo Hagelstrom, Inés Juliana (MDPI, 2023-01-23)
Ride comfort improvement in driving scenarios is gaining traction as a research topic. This work presents a direct methodology that utilizes measured car signals and combines data processing techniques and machine learning ... -
Drug Delivery from Hyaluronic Acid-BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications
; ; ; Benito Cid, Sandra; ; Vilas Vilela, José Luis ; (MDPI, 2022-04-06)
Hyaluronic acid (HA) injectable biomaterials are currently applied in numerous biomedical areas, beyond their use as dermal fillers. However, bacterial infections and painful inflammations are associated with healthcare ... -
Drug pollution and pharmacotherapy inpsychiatry: A“platypus”in the room
(Cambridge University Press, 2020)Preoccupation about potential deleterious effects of pharmaceuticals in the environment is growing fast. Psychiatric pharmaceuticals have received particular attention because of their increasing use and their potential ... -
Drug-refractory myasthenia gravis: Clinical characteristics, treatments, and outcome
(Wiley, 2022-02)[EN] Objective: To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment. Methods: ... -
Dry reforming of methane over sub-stoichiometric NiAl2O4-mediated Ni/Al2O3 catalysts
Choya Atencia, Andoni; ; ; Gutiérrez Ortiz, José Ignacio ; López Fonseca, Rubén (Elsevier, 2023-10-31)
A series of Ni/Al2O3 catalysts were prepared from substoichiometric NiAl2O4 precursors (Ni/Al molar ratio between 0.5 and 0.05) were examined for the dry reforming of methane. The calcined spinel precursors and the ... -
Drying and Rainfall Shape the Structure and Functioning of Nitrifying Microbial Communities in Riverbed Sediments
Arce, Maria Isabel; Von Schiller Calle, Daniel Gaspar; Bengtsson, Mia M.; Hinze, Christian; Jung, Hoseung; Eloy Alves, Ricardo J.; Urich, Tim; Singer, Gabriel (Frontiers Media, 2018-11-16)
Non-flow periods in fluvial ecosystems are a global phenomenon. Streambed drying and rewetting by sporadic rainfalls could drive considerable changes in the microbial communities that govern stream nitrogen (N) availability ... -
Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
; Aguilera-Correa, John Jairo; ; ; ; Esteban, Jaime ; ; ; San Sebastian, Eider ; ; Gómez Ruiz, Santiago (MDPI, 2023-02-07)
Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), ... -
Dual educational rationality and acculturation in Mapuche people in Chile
(Frontiers Media, 2023-03)Even though Mapuche people represent the largest indigenous population in Chile, the “logic of double rationality” in their educational knowledge and its link with acculturation dynamics, has been scarcely studied. The aim ... -
Dual effect of TAT functionalized DHAH lipid nanoparticles with neurotrophic factors in human BBB and microglia cultures.
Hernando Revilla, Sara; Nikolakopoulou, Polyxeni; Voulgaris, Dimitrios; Hernández Martín, Rosa María; Igartua Olaechea, Manuela ; Herland, Anna (BMC, 2022-03-17)
[EN] BACKGROUND: Neurodegenerative diseases (NDs) are an accelerating global health problem. Nevertheless, the stronghold of the brain- the blood-brain barrier (BBB) prevents drug penetrance and dwindles effective treatments. ... -
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells
(American Society for Microbiology, 2022-07)An essential step in the infection life cycle of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the proteolytic activation of the viral spike (S) protein, which enables membrane fusion and entry into ... -
Dual redox-active porous polyimides as high performance and versatile electrode material for next-generation batteries
(Royal Society of Chemistry, 2023-03)Energy storage will be a primordial actor of the ecological transition initiated in the energy and transport sectors. As such, innovative approaches to design high-performance electrode materials are crucial for the ... -
Dual-path methods for propagating quantum microwaves
Di Candia, Roberto; Menzel, E.P.; Zhong, L.; Deppe, F.; Marx, A.; Gross, R.; Solano Villanueva, Enrique Leónidas (IOP Publishing, 2014-01)
We study quantum state tomography, entanglement detection and channel noise reconstruction of propagating quantum microwaves via dual-path methods. The presented schemes make use of the following key elements: propagation ... -
Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation
Nunes Xavier, Caroline E.; Zaldumbide Dueñas, Laura; Aurtenetxe, Olaia; López Almaraz, Ricardo; López Fernández de Villaverde, José Ignacio; Pulido Murillo, Rafael (MDPI, 2019-03-01)
Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) ...