BackBrowsing Artículos by Author "Chara Ventura, Juan Carlos"
Now showing items 1-8 of 8
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Astrocytic Atrophy as a Pathological Feature of Parkinson's Disease with LRRK2 Mutation
Ramos González, Paula; Mato Santos, Susana
; Chara Ventura, Juan Carlos; Verkhratsky, Alexei; ; Cavaliere, Fabio (Springer, 2021-03-30)
The principal hallmark of Parkinson's disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to dopaminergic neurodegeneration through decreased ... -
Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
; ; ; ; ; ; ; ; Mato Santos, Susana; ; ; ; (SpringerNature, 2022)
[EN] Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on oligodendroglial cells in vivo, and the molecular mechanisms underlying ... -
Clemastine Induces an Impairment in Developmental Myelination
; ; Montilla López, Alejandro; ; ; ; ; Pérez Samartín, Alberto Luis ; Domercq García, María (Frontiers Media, 2022)
[EN] Abnormalities in myelination are associated to behavioral and cognitive dysfunction in neurodevelopmental psychiatric disorders. Thus, therapies to promote or accelerate myelination could potentially ameliorate symptoms ... -
Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis
Lutz, Sarah E.; González Fernández, Estibaliz; Chara Ventura, Juan Carlos; Pérez Samartín, Alberto Luis; Tarassishin, Leonid; Negoro, Hiromitsu; Patel, Naman K.; Suadicani, Sylvia O.; Lee, Sunhee C.; ; Scemes, Eliana (Public Library of Science, 2013-06)
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. ... -
Delta(9)-Tetrahydrocannabinol promotes functional remyelination in the mouse brain
; ; ; ; ; ; Mato Santos, Susana; ; ; (Wiley, 2021-10)
Background and purpose Research on demyelinating disorders aims to find novel molecules that are able to induce oligodendrocyte precursor cell differentiation to promote central nervous system remyelination and functional ... -
Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
Cipriani, Raffaela; ; ; (Biomed Central, 2017-07-24)
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ... -
FTY720 attenuates excitotoxicity and neuroinflammation
Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; (BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ... -
Genetically modified macrophages accelerate myelin repair
(Wiley, 2022-08-08)[EN] Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in ...