BackBrowsing Artículos by Author "Cortés Díaz, Jesús María"
Now showing items 1-20 of 21
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A novel brain partition highlights the modular skeleton shared by structure and function
(Nature Publishing Group, 2015-06-03)Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent progress in neuroimaging has helped advance our ... -
BRAF V600E mutational load as a prognosis biomarker in malignant melanoma
Sevilla Mambrilla, Arrate
; ; Ezcurra García Unzueta, Pilar Ariadna ; ; ; ; ; ; ; ; Asumendi Mallea, Aintzane ; ; Boyano López, María Dolores ; Alonso Alegre, Santos (Public Library Science, 2020-03-13)
Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma ... -
Brain connectivity and cognitive functioning in individuals six months after multiorgan failure
(Elsevier, 2019-12)Abstract Multiorgan failure (MOF) is a life-threating condition that affects two or more systems of organs not involved in the disorder that motivates admission to an Intensive Care Unit (ICU). Patients who survive MOF ... -
Brain Mapping of Behavioral Domains Using Multi-Scale Networks and Canonical Correlation Analysis
; ; Sierra Araujo, Basilio; ; ; (Frontiers Media, 2022-06)
Simultaneous mapping of multiple behavioral domains into brain networks remains a major challenge. Here, we shed some light on this problem by employing a combination of machine learning, structural and functional brain ... -
Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
(Frontiers Media, 2017-03-06)Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version ... -
Heart-brain synchronization breakdown in Parkinson's disease
(Nature, 2022-05)Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson's disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization ... -
Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder
(Wiley, 2021-07)Individual-based morphological brain networks built from T1-weighted magnetic resonance imaging (MRI) reflect synchronous maturation intensities between anatomical regions at the individual level. Autism spectrum disorder ... -
Melanoma Clinical Decision Support System: An Artificial Intelligence-Based Tool to Diagnose and Predict Disease Outcome in Early-Stage Melanoma Patients
; ; ; ; ; Apraiz García, Aintzane; ; ; ; ; ; ; ; Sevilla Mambrilla, Arrate ; ; ; ; Alonso Alegre, Santos ; Asumendi Mallea, Aintzane ; Boyano López, María Dolores (MDPI, 2023-04-06)
This study set out to assess the performance of an artificial intelligence (AI) algorithm based on clinical data and dermatoscopic imaging for the early diagnosis of melanoma, and its capacity to define the metastatic ... -
Metastable Resting State Brain Dynamics
(Frontiers Media, 2019-09)Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state ... -
MMADHC Premature Termination Codons in the Pathogenesis of Cobalamin D Disorder: Potential of Translational Readthrough Reconstitution
(Elsevier, 2021-03)Mutations in the MMADHC gene cause cobalamin D disorder (cblD), an autosomal recessive inborn disease with defects in intracellular cobalamin (cbl, vitamin B12) metabolism. CblD patients present methylmalonic aciduria ... -
Myocardial MIBG scintigraphy in genetic Parkinson’s disease as a model for Lewy body disorders
(Springer-Verlag, 2018-10-15)Purpose To identify myocardial sympathetic denervation patterns suggestive of Lewy body (LB) pathology in patients with genetic and idiopathic parkinsonisms by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. Methods We ... -
Neurodegeneration Trajectory in Pediatric and Adult/Late DM1: a Follow-up MRI Study Across a Decade
Labayru Isusquiza, Garazi; Jiménez Marín, Antonio; Fernández, Esther; Villanua Bernues, Jorge Alberto; Zulaica, Miren; Cortés Díaz, Jesús María; Díez, Ibai; Sepulcre, Jorge; López de Munain Arregui, Adolfo José; Sistiaga Berrondo, Andone (Wiley, 2020-10)
Objective: To characterize the progression of brain structural abnormalities in adults with pediatric and adult/late onset DM1, as well as to examine the potential predictive markers of such progression. Methods: 21 DM1 ... -
On the Dynamics of the Adenylate Energy System: Homeorhesis vs Homeostasis
Martínez de la Fuente Martínez, Ildefonso Abel; Cortés Díaz, Jesús María; Valero, Edelmira; Desroches, Mathieu; Rodrigues, Serafim; Malaina Celada, Iker; Martínez Fernández, Luis (Public Library Science, 2014-10-10)
Biochemical energy is the fundamental element that maintains both the adequate turnover of the biomolecular structures and the functional metabolic viability of unicellular organisms. The levels of ATP, ADP and AMP reflect ... -
Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
(Wiley, 2019-05-28)Background Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region-specific thickness analysis of retinal layers ... -
Protein tyrosine phosphatase modulates cell growth and associates with poor outcome in human neuroblastoma
Nunes Xavier, Caroline E.; Aurtenetxe, Olaia; Zaldumbide Dueñas, Laura; López Almaraz, Ricardo; Erramuzpe Aliaga, Asier; Cortés Díaz, Jesús María; López Fernández de Villaverde, José Ignacio; Pulido Murillo, Rafael (BMC, 2019-12-14)
Background Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the ... -
Serum markers improve current prediction of metastasis development in early-stage melanoma patients: a machine learning-based study
; ; ; ; Apraiz García, Aintzane; Pérez-Yarza Pérez-Irezabal, Gorka ; Ezcurra García Unzueta, Pilar Ariadna ; ; ; ; ; ; ; ; Asumendi Mallea, Aintzane ; Boyano López, María Dolores (Wiley, 2020-06)
Metastasis development represents an important threat for melanoma patients, even when diagnosed at early stages and upon removal of the primary tumor. In this scenario, determination of prognostic biomarkers would be of ... -
Snail heterogeneity in clear cell renal cell carcinoma
(Biomed Central, 2016-03-08)Background: Intratumor heterogeneity may be responsible of the unpredictable aggressive clinical behavior that some clear cell renal cell carcinomas display. This clinical uncertainty may be caused by insufficient sampling, ... -
The Metabolic Core and Catalytic Switches Are Fundamental Elements in the Self-Regulation of the Systemic Metabolic Structure of Cells
Martínez de la Fuente Martínez, Ildefonso Abel; Cortés Díaz, Jesús María; Pérez Pinilla, Martín Blas; Ruiz Rodríguez, Vicente; Veguillas Losada, Juan Emilio (Public Library of Science, 2011-11-18)
Background: Experimental observations and numerical studies with dissipative metabolic networks have shown that cellular enzymatic activity self-organizes spontaneously leading to the emergence of a metabolic core formed ... -
Toward neuroprosthetic real-time communication from in silico to biological neuronal network via patterned optogenetic stimulation
(Nature, 2020-05-05)Restoration of the communication between brain circuitry is a crucial step in the recovery of brain damage induced by traumatic injuries or neurological insults. In this work we present a study of real-time unidirectional ... -
Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration
Jiménez Marín, Antonio; Díez Palacio, Ibai; Labayru Isusquiza, Garazi; Sistiaga Berrondo, Andone; Caballero, Maria C.; Andres-Benito, Pol; Sepulcre, Jorge; Ferrer, Isidro; López de Munain Arregui, Adolfo José; Cortés Díaz, Jesús María (Wiley, 2021-12)
Aim To delineate the neurogenetic profiles of brain degeneration patterns in myotonic dystrophy type I (DM1). Methods In two cohorts of DM1 patients, brain maps of volume loss (VL) and neuropsychological deficits (NDs) ...