Browsing Artículos by Author "Corzana, Francisco"

Now showing items 1-4 of 4

    • Thumbnail

      Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling 

      Coelho, Helena; De las Rivas, Matilde; Grosso, Ana S.; Diniz, Ana; Soares, Cátia O.; Francisco, Rodrigo A.; Dias, Jorge S.; Compañón, Ismael; Sun, Lingbo; Narimatsu, Yoshiki; Vakhrushev, Sergey Y.; Clausen, Henrik; Cabrita, Eurico J.; Jiménez Barbero, Jesús ORCID; Corzana, Francisco; Hurtado Guerrero, Ramón; Marcelo, Filipa (American Chemical Society, 2022-02-24)
      [EN] The large family of polypeptide GalNAc-transferases (GalNAc-Ts) controls with precision how GalNAc O-glycans are added in the tandem repeat regions of mucins (e.g., MUC1). However, the structural features behind the ...
    • Thumbnail

      Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA 

      Anso, Itxaso; Basso, Luis G. M.; Wang, Lei; Marina, Alberto; Páez Pérez, Edgar D.; Jager, Christian; Gavotto, Floriane; Tersa Peñacoba, Montserrat; Perrone, Sebastian; Contreras Gómez, Xabier ORCID; Prandi, Jacques; Gilleron, Martine; Linster, Carole L.; Corzana, Francisco; Lowary, Todd L.; Trastoy, Beatriz; Guerín, Marcelo Eduardo (American Association for the Advancement of Science, 2021-10)
      [EN]Glycolipids are prominent components of bacterial membranes that play critical roles not only in maintaining the structural integrity of the cell but also in modulating host-pathogen interactions. PatA is an essential ...
    • Thumbnail

      Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by 19F NMR 

      Liebau, Jobst; Tersa Peñacoba, Montserrat; Trastoy, Beatriz; Patrick, Joan; Rodrigo Unzueta, Ane; Corzana, Francisco; Sparrman, Tobias; Guerín, Marcelo Eduardo; Mäler, Lena (American Society for Biochemistry and Molecular Biology, 2020-07-17)
      Fold-switch pathways remodel the secondary structure topology of proteins in response to the cellular environment. It is a major challenge to understand the dynamics of these folding processes. Here, we conducted an in-depth ...
    • Thumbnail

      Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition 

      Bermejo, Iris A.; Usabiaga Gutiérrez, Imanol; Compañón, Ismael; Castro-López, Jorge; Insausti Beiro, Aran; Fernández González, José Andrés ORCID; Avenoza, Alberto; Busto, Jesús H.; Jiménez Barbero, Jesús ORCID; Asensio, Juan L.; Peregrina, Jesús M.; Jiménez Oses, Gonzalo; Hurtado Guerrero, Ramón; Cocinero Pérez, Emilio José; Corzana, Francisco (ACS, 2018-07-13)
      The tumor-associated carbohydrate Tn antigens include two variants, αGalNAc-O-Thr and αGalNAc-O-Ser. In solution, they exhibit dissimilar shapes and dynamics and bind differently to the same protein receptor. Here, we ...