Browsing Artículos by Author "Etxebarria Gallego, Aitor"

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      Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells 

      Martín Plágaro, César Augusto; Etxaniz Iriondo, Asier; Belloso Uribe, Kepa; Etxebarria Gallego, Aitor; González Bullón, David ORCID; Arluzea de Jauregizar, Jon Andoni ORCID; Goñi Urcelay, Félix María ORCID; Arechaga Martínez, Juan Miguel ORCID; Ostolaza Echabe, Elena Amaya (Nature Publishing Group, 2015-09-08)
      Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium ...
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      Identification and in vitro characterization of two new PCSK9 Gain of Function variants found in patients with Familial Hypercholesterolemia 

      Di Taranto, Maria Donata; Benito Vicente, Asier; Giacobbe, Carola; Belloso Uribe, Kepa; Rubba, Paolo; Etxebarria Gallego, Aitor; Guardamagna, Ornella; Gentile, Marco; Martín Plágaro, César Augusto; Fortunato, Giuliana (Nature, 2017-11)
      Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by pathogenic variants in genes encoding for LDL receptor (LDLR), Apolipoprotein B and Proprotein convertase subtilisin/kexin type 9 (PCSK9). Among ...
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      Serological Antibodies against Kidney, Liver, and Spleen Membrane Antigens as Potential Biomarkers in Patients with Immune Disorders 

      Hernández Suárez, Leidi; Díez Martín, Eguzkiñe; Egiguren Ortiz, June; Fernández, Roberto; Etxebarria Gallego, Aitor; Astigarraga Arribas, Egoitz; Miguélez Palomo, Cristina; Ramírez Garcia, Andoni; Barreda Gómez, Gabriel (MDPI, 2024-02-07)
      Immune disorders arise from complex genetic and environmental factors, which lead to dysregulation at the cellular and inflammatory levels and cause tissue damage. Recent research highlights the crucial role of reactive ...
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      Structural changes induced by acidic pH in human apolipoprotein B-100 

      Fernández Higuero, José Ángel; Benito Vicente, Asier; Etxebarria Gallego, Aitor; González Milicua, José Carlos; Ostolaza Echabe, Elena Amaya; Arrondo, Jose Luis R.; Martín Plágaro, César Augusto (Nature Research, 2016-11-08)
      Acidification in the endosome causes lipoprotein release by promoting a conformational change in the LDLR allowing its recycling and degradation of LDL. Notwithstanding conformational changes occurring in the LDLR have ...
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      The importance of an integrated analysis of clinical, molecular, and functional data for the genetic diagnosis of familial hypercholesterolemia 

      Benito Vicente, Asier; Alves, Ana Catarina; Etxebarria Gallego, Aitor; Medeiros, Ana; Martín Plágaro, César Augusto; Bourbon, Mafalda (Nature, 2015-12)
      Purpose Familial hypercholesterolemia (FH) is one of the most common monogenic disorders, and the high concentrations of low-density lipoprotein (LDL) cholesterol presented since birth confers on these patients an increased ...