Browsing Artículos by Author "Holak, Tad A."

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      Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments 

      Kitel, Radoslaw; Rodríguez Rodríguez, Ismael; Del Corte Solaguren-Beascoa, Xabier; Atmaj, Jack; Zarnik, Magdalena; Surmiak, Ewa; Muszak, Damian; Magiera-Mularz, Katarzyna; Popowicz, Grzegorz M.; Holak, Tad A.; Musielak, Bogdan (American Chemical Society, 2022-09-08)
      Development of small molecules targeting the PD-L1/PD-1 interface is advancing both in industry and academia, but only a few have reached early-stage clinical trials. Here, we take a closer look at the general druggability ...