Browsing Artículos by Author "Obradors, Carla"

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      Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2 

      Azkona, Garikoitz ORCID; Amador Arjona, Alejandro; Obradors, Carla; Varea, Emilio; Arqué, Gloria; Pinacho, Raquel; Fillat, Cristina; De la Luna, Susana; Estivill, Xavier; Dierssen, Mara (Wiley, 2010-03-10)
      BACE2 is homologous to BACE1, a beta-secretase that is involved in the amyloidogenic pathway of amyloid precursor protein (APP), and maps to the Down syndrome critical region of chromosome 21. Alzheimer disease neuropathology ...