Browsing Artículos by Author "Vakhrushev, Sergey Y."

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      An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles 

      Madsen, Thomas D.; Hansen, Lasse H.; Hintze, John; Ye, Zilu; Jebari Benslaiman, Shifa; Andersen, Daniel B.; Joshi, Hiren J.; Ju, Tongzhong; Goetze, Jens P.; Martin, Cesar; Rosenkilde, Mette M.; Holst, Jens J.; Kuhre, Rune E.; Goth, Christoffer K.; Vakhrushev, Sergey Y.; Schjoldager, Katrine T. (Nature, 2020-08-20)
      Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused ...
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      Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling 

      Coelho, Helena; De las Rivas, Matilde; Grosso, Ana S.; Diniz, Ana; Soares, Cátia O.; Francisco, Rodrigo A.; Dias, Jorge S.; Compañón, Ismael; Sun, Lingbo; Narimatsu, Yoshiki; Vakhrushev, Sergey Y.; Clausen, Henrik; Cabrita, Eurico J.; Jiménez Barbero, Jesús ORCID; Corzana, Francisco; Hurtado Guerrero, Ramón; Marcelo, Filipa (American Chemical Society, 2022-02-24)
      [EN] The large family of polypeptide GalNAc-transferases (GalNAc-Ts) controls with precision how GalNAc O-glycans are added in the tandem repeat regions of mucins (e.g., MUC1). However, the structural features behind the ...