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Now showing items 11-20 of 23
Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease
(Dove Medical Press, 2014)
Current research efforts are focused on the application of growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), as neuroregenerative approaches that will ...
GSE4-Loaded Nanoparticles a Potential Therapy for Lung Fibrosis that Enhances Pneumocyte Growth, Reduces Apoptosis and DNA Damage
(Wiley, 2021-03)
Idiopathic pulmonary fibrosis is a lethal lung fibrotic disease, associated with aging with a mean survival of 2-5 years and no curative treatment. The GSE4 peptide is able to rescue cells from senescence, DNA and oxidative ...
Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
(Elsevier, 2022-04-30)
Epistaxis is one of the most common otorhinolaryngology emergencies worldwide. Although there are currently several treatments available, they present several disadvantages. This, in addition to the increasing social need ...
Computational and Experimental Evaluation of the Immune Response of Neoantigens for Personalized Vaccine Design
(MDPI, 2023-05-19)
In the last few years, the importance of neoantigens in the development of personalized antitumor vaccines has increased remarkably. In order to study whether bioinformatic tools are effective in detecting neoantigens that ...
High resolution and fidelity 3D printing of Laponite and alginate ink hydrogels for tunable biomedical applications
(Elsevier, 2023-06)
The formulation of hydrogels that meet the necessary flow characteristics for their extrusion-based 3D printing while providing good printability, resolution, accuracy and stability, requires long development processes. ...
Tumour-derived extracellular vesicle based vaccines for melanoma treatment
(Springer, 2023-05)
The interest of extracellular vesicles (EVs) in cancer immunotherapy is increasing every day. EVs are lipid bilayer vesicles released by most cells, which contain the molecular signature of their parent cell. Melanoma-derived ...
Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing
(BMC, 2022-04)
[EN] Background Mesenchymal stromal cells (MSCs) and their extracellular vesicles (MSC-EVs) have demonstrated to elicit immunomodulatory and pro-regenerative properties that are beneficial for the treatment of chronic ...
Hybrid 3D Printed and Electrospun Multi-Scale Hierarchical Polycaprolactone Scaffolds to Induce Bone Differentiation
(MDPI, 2022-12-19)
Complex scaffolds composed of micro- and nano-structures are a key target in tissue engineering and the combination of sequential 3D printing and electrospinning enables the fabrication of these multi-scale structures. In ...
Clinical progress in MSC-based therapies for the management of severe COVID-19.
(Elsevier, 2022-12)
Considering the high impact that severe Coronavirus disease 2019 (COVID-19) cases still pose on public health and their complex pharmacological management, the search for new therapeutic alternatives is essential. Mesenchymal ...
Preparation and Characterization of Resveratrol Loaded Pectin/Alginate Blend Gastro-Resistant Microparticles
(MDPI, 2018-08)
Background: The use of resveratrol as a dietary supplement is limited because it is easily oxidized and, after oral ingestion, it is metabolized into enterocytes and hepatocytes. Thus, new formulations are needed in order ...