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Ferromagnetic supramolecular metal-organic frameworks for active capture and magnetic sensing of emerging drug pollutants
(Elsevier ; Cell Press, 2021-05-19)
[EN] Capture and sensing of emerging pollutants is one of the increasing environmental concerns due to the adverse ecological and human health effects. Here, we report the synthesis of a supramolecular metal-organic framework ...
Late-Stage C-H Acylation of Tyrosine-Containing Oligopeptides with Alcohols
(American Chemical Society, 2021-09-17)
The selective tagging of amino acids within a peptide framework while using atom-economical C-H counterparts poses an unmet challenge within peptide chemistry. Herein, we report a novel Pd-catalyzed late-stage C-H acylation ...
Absence of Intermediates in the BINOL-Derived Mg(II)/Phosphate-Catalyzed Desymmetrizative Ring Expansion of 1-Vinylcyclobutanols
(American Chemical Society, 2021-12)
[EN] The catalyzed desymmetrizative ring expansion of alkenylcyclobutanols promoted by halofunctionalization of the alkene moiety with Nbromosuccinimide has been experimentally and computationally studied. The reaction ...
The Pseudotransannular Ring Opening of 1-Aminocyclohept-4-ene-derived Epoxides in the Synthesis of Tropane Alkaloids: Total Synthesis of (+/-)-Ferrugine
(Wiley, 2021-05-26)
We have optimized a synthetic approach to (+/-)-Ferrugine in 8 steps starting from 5-aminocyclohept-1-ene and using the Bronsted acid-catalyzed pseudotransannular ring-opening of the epoxide derived from this cycloheptene ...
Pd(II)-Catalyzed Fujiwara-Moritani Reactions for the Synthesis and Functionalization of Substituted Coumarins.
(American Chemical Society, 2021-11-09)
[EN]Highly substituted coumarins, privileged and versatile scaffolds for bioactive natural products and fluorescence imaging, are obtained via a Pd(II)-catalyzed direct C–H alkenylation reaction (Fujiwara–Moritani reaction), ...
Microwave-assisted Palladium catalysed C-H acylation with aldehydes. Synthesis and diversification of 3-acylthiophenes
(Royal Society of Chemistry, 2021-12-22)
The use of MW allows the efficient palladium(II)-catalysed C-3 acylation of thiophenes with aldehydes via C(sp2)-H activation for the synthesis of (cyclo)alkyl/aryl thienyl ketones (43 examples). Compared to standard thermal ...
Enantioselective construction of the 8-azabicyclo[3.2.1]octane scaffold: application in the synthesis of tropane alkaloids
(Royal Society of Chemistry, 2021-03-15)
The 8-azabicyclo[3.2.1]octane scaffold is the central core of the family of tropane alkaloids, which display a wide array of interesting biological activities. As a consequence, research directed towards the preparation ...
An Approach to the Synthesis of a Hepatitis C Virus Inhibitor through a Proline-Catalyzed 1,3-Dipolar Cycloaddition Using Acrolein
(Thieme, 2021-09-06)
An efficient and easy protocol for performing 1,3-dipolar cycloaddition using azomethine ylides and acrolein is presented. The reaction catalyzed by d-proline allows the synthesis of C-3 unsubstituted pyrrolidines. The ...
Palladium-mediated synthesis and biological evaluation of C-10b substituted Dihydropyrrolo[1,2-b]isoquinolines as antileishmanial agents
(Elsevier, 2021-04-16)
The development of new molecules for the treatment of leishmaniasis is, a neglected parasitic disease, is
urgent as current anti-leishmanial therapeutics are hampered by drug toxicity and resistance. The pyrrolo[
1,2-b ...
Tailoring of a Phenothiazine Core for Electrical Conductivity and Thermal Stability: Hole-Selective Layers in Perovskite Solar Cells
(ACS Publications, 2021-07-07)
Hole-selective layers are an indispensable component for the fabrication of effective perovskite solar cells. We designed and developed two phenothiazine-based hole transport materials: PTADAnCBZ with an electron-donating ...