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Myocardial MIBG scintigraphy in genetic Parkinson’s disease as a model for Lewy body disorders
(Springer-Verlag, 2018-10-15)
Purpose To identify myocardial sympathetic denervation patterns suggestive of Lewy body (LB) pathology in patients with genetic and idiopathic parkinsonisms by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. Methods We ...
Small fiber neuropathy and phosphorylated alpha-synuclein in the skin of E46K- SNCA mutation carriers
(Elsevier, 2019-06-05)
Background and objective: In 2004 we described the E46K mutation in alpha-synuclein gene (E46K-SNCA), a rare point mutation causing an aggressive Lewy body disease with early prominent non-motor features and small fiber ...
Autonomic dysfunction is associated with neuropsychological and neuropsychiatric impairment in patients with Lewy body diseases
(Springer-Verlag GmbH Germany, 2020-03-13)
Objective: This study aimed to analyze the association of autonomic dysfunction with cognition, depression, apathy, and fatigue in Lewy body disease (LBD).
Methods: We included 61 patients [49 with idiopathic Parkinson’s ...
Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson’s disease
(Nature, 2024-01)
Retinal thickness may serve as a biomarker in Parkinson’s disease (PD). In this prospective longitudinal study, we aimed to determine if PD patients present accelerated thinning rate in the parafoveal ganglion cell-inner ...
Retinal thickness as a biomarker of cognitive impairment in manifest Huntington’s disease
(Springer Nature, 2023)
Background
Cognitive decline has been reported in premanifest and manifest Huntington’s disease but reliable biomarkers are lacking. Inner retinal layer thickness seems to be a good biomarker of cognition in other ...
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome
(BMC, 2023)
Background
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic and neuropathic symptoms.
Methods
The study included 87 ...