Search
Now showing items 231-240 of 249
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia
(Springer Nature, 2020-03)
Identification of genomic and epigenomic determinants of drug resistance provides important insights for improving cancer treatment. Using agnostic genome-wide interrogation of mRNA and miRNA expression, DNA methylation, ...
Impact of polymorphisms in apoptosis-related genes on the outcome of childhood acute lymphoblastic leukaemia
(Wiley, 2018-05-29)
Despite intensification of therapy, 20% of children with acute lymphoblastic leukaemia (ALL) relapse (Ceppi et al, 2015). The different response to chemotherapy may be partially explained by inherited genetic variants, ...
Improving the mechanical and biological functions of cell sheet constructs: The interplay of human-derived periodontal ligament stem cells, endothelial cells and plasma rich in growth factors
(Elsevier, 2024-05)
Objective
The aim of this study was to produce and characterize triple-layered cell sheet constructs with varying cell compositions combined or not with the fibrin membrane scaffold obtained by the technology of Plasma ...
Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project
(Oxford University Press, 2017-10)
Background: There is evidence that birthweight is positively associated with body mass
index (BMI) in later life, but it remains unclear whether this is explained by genetic factors
or the intrauterine environment. We ...
Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts
(Elsevier, 2021-11)
Comparing twins from same- and opposite-sex pairs can provide information on potential sex differences in a
variety of outcomes, including socioeconomic-related outcomes such as educational attainment. It has been
suggested ...
Systematic review of the potential of MicroRNAs in the management of patients with follicular lymphoma
(Elsevier, 2021-03)
Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma and usually presents as an indolent disease. However, some patients present poor outcomes, and FL can transform into more aggressive lymphomas, such ...
Two-Sample Mendelian Randomization detects bidirectional causality between gut microbiota and celiac disease in individuals with high genetic risk
(Frontiers Media, 2023-06)
Background: Celiac Disease (CeD) is an autoimmune disorder triggered by gluten intake in genetically susceptible individuals. Highest risk individuals are homozygous for the Human Leucocyte Antigen (HLA) DQ2.5 haplotype ...
High frequency of mitochondrial haplogroups H and H2 in medieval individuals from the Cathedral of Santa María (Basque Country). Their contribution to the study of inflammatory arthropathies
(Elsevier, 2023-02)
The haplogroup H has been associated with high mitochondrial energy efficiency, which may have favoured survival and reproduction under adverse environmental conditions. On the other hand, it enhances the production of ...
The sheep miRNAome: Characterization and distribution of miRNAs in 21 tissues
(Elsevier, 2023-01)
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate gene expression. In livestock species, miRNAs also show great potential as biomarkers for animal health and product quality. In sheep, few ...
Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression
(Nature, 2023)
Recent evidence demonstrates potential links between mitochondrial dysfunction and inflammatory bowel diseases (IBD). In addition, bidirectional interactions between the intestinal microbiota and host mitochondria may ...