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Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination
(MDPI, 2020-08-24)
The endocannabinoid system is associated with protective effects in multiple sclerosis (MS) that involve attenuated innate immune cell responses. Astrocytes and microglia are modulated by endocannabinoids and participate ...
Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
(Wiley, 2019-05-28)
Background Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region-specific thickness analysis of retinal layers ...
Familial amyloidosis with polyneuropathy type 1 caused by transthyretin mutation Val50Met (Val30Met): 4 cases in a non-endemic area
(Elsevier, 2018-11)
Introduction: Transthyretin-related familial amyloid polyneuropathy (TTR-FAP) typically arises as an autonomic neuropathy primarily affecting small fibres and it occurs in adult patients in their second or third decades ...
Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania
(Frontiers Media, 2019-03-26)
Poor adherence is a major problem in patients with manic episodes that impairs functionality and has unknown effects on oxidative stress. The objective of this study was to analyze the relationship between adherence to ...
Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action
(Elsevier, 2020-06-12)
[EN] Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substan- tial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is ...
Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease
(Hindawi, 2018)
Synapse loss is an early manifestation of pathology in Alzheimer's disease (AD) and is currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning during development via the complement ...
In vivo PET Imaging of Gliogenesis After Cerebral Ischemia in Rats
(Frontiers Media, 2020-07-30)
In vivopositron emission tomography of neuroinflammation has mainly focused on the evaluation of glial cell activation using radiolabeled ligands. However, the non-invasive imaging of neuroinflammatory cell proliferation ...
Retinal Thickness Predicts the Risk of Cognitive Decline in Parkinson Disease
(Wiley, 2021-01)
Objective This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD).
Methods Patients with ...
A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease
(Frontiers Media, 2022-04-14)
Glial cells are essential to understand Alzheimer's disease (AD) progression, given their role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to manipulate models that allow studying the ...
A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis
(MDPI, 2021-07-06)
Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The ...