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Generation of Tertiary and Quaternary Stereocenters via Palladium-Catalyzed Intramolecular Heck-type Reactions for the Stereocontrolled Synthesis of Pyrrolo[1,2-b]isoquinolines
(Wiley, 2016-04-05)
The generation of quaternary and tertiary stereocenters on C-10 of the pyrroloisoquinoline skeleton through intramolecular Mizoroki-Heck reactions of 2-alkenyl substituted pyrroles and pyrrolidines has been studied. The ...
Perturbation Theory Model of Reactivity and Enantioselectivity of Palladium-catalyzed Heck-Heck cascade reactions
(Royal Society of Chemistry, 2016-04-13)
Enantioselective intramolecular Heck-Heck cascade reactions have emerged as an excellent tool for the construction of polycyclic frameworks, such as Lycorane alkaloids, Xestoquinone and analogues. However, it is particularly ...
Intramolecular Addition of Heteroaryllithiums onto Activated Alkenes. Access to Heterofused Indolizines and Pyrroloazepines
(Wiley, 2017-02-23)
Heteroaryllithiums, obtained via MesLi mediated halogen- lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron rich (thiophenyl) and electron deficient (pyridinyl, quinolinyl) ...
Favoring Trienamine Activation through Unconjugated Dienals: Organocatalytic Enantioselective Remote Functionalization of Alkenes
(Wiley-VCH, 2014-01-29)
Unconjugated 2,5-dienals are more reactive substrates
than the corresponding fully conjugated a,b,g,dunsaturated
aldehydes towards organocatalytic activation
through trienamine intermediates. This difference in ...
Catalytic Generation of Donor-Acceptor Cyclopropanes under N-Heterocyclic Carbene Activation and their Stereoselective Reaction with Alkylideneoxindoles
(Wiley-VCH, 2017-04-10)
Formylcyclopropanes undergo activation
in the presence of an N-heterocyclic carbene catalyst
generating a donor-acceptor cyclopropane intermediate
with the ability to undergo ring-opening
followed by formal [4+2] ...
Enantioselective Oxidative (4+3) Cycloadditions between Allenamides and Furans through Bifunctional Hydrogen-Bonding/Ion-Pairing Interactions
(Wiley-VCH, 2017-07-03)
BINOL-based N-trifluoromethanesulfonyl phosphoramides
catalyze the enantioselective (4+3) cycloaddition
between furans and oxyallyl cations, the latter being generated
in situ by oxidation of allenamides. The chiral ...
Regioselectivity Change in the Organocatalytic Enantioselective (3+2) Cycloaddition with Nitrones Through Cooperative Hydrogen-Bonding Catalysis/Iminium Activation.
(Wiley-VCH, 2017-01-12)
The reaction of nitrones with enals through iminium
activation can be modulated by using cooperative
hydrogen-bonding catalysis to induce the participation of
a nitrone ylide (C-N-C) instead of the classical C-N-O
dipole. ...
MCDCalc: Markov Chain Molecular Descriptors Calculator for Medicinal Chemistry
(Bentham Science, 2020)
Cheminformatics models are able to predict different outputs (activity, property, chemical reactivity) in single molecules or complex molecular systems (catalyzed organic synthesis, metabolic reactions, nanoparticles, ...