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Behavior And Ultrastructure Of Human Bone Marrow-Derived Mesenchymal Stem Cells Immobilized In Alginate-Poly-L-Lysine-Alginate Microcapsules
(Taylor & Francis, 2014-04-24)
Context: Human bone marrow mesenchymal stem cells (hBM-MSCs) show a great promise for the treatment of a variety of diseases. Despite the previous trials to encapsulate hBM-MSCs in alginate-poly-l-lysine-alginate (APA) ...
Improvement of the monitoring and biosafety of encapsulated cells using the SFGNESTGL triple reporter system
(Elsevier, 2010-05-23)
Cell microencapsulation may represent a breakthrough to overcome problems associated with cell therapy. Advances in material biocompatibility and production protocols have put this field close to its clinical application. ...
Inactivation of encapsulated cells and their therapeutic effects by means of TGL triple-fusion reporter/biosafety gene
(Elsevier, 2012-11-19)
The immobilization of cells within alginate-poly-l-lysine-alginate (APA) microcapsules has been demonstrated to be an effective technology design for long term delivery of therapeutic products. Despite promising advances, ...
Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D
(Elsevier, 2012-05-07)
Recreating the most critical aspects of the native extracellular matrix (ECM) is fundamental to understand and control the processes regulating cell fate and cell function. From the ill-defined complexity to the controlled ...
Optimization of 100 µm alginate-poly-L-lysine-alginate capsules for intravitreous administration
(Elsevier, 2011-09-24)
The field of cell microencapsulation is advancing rapidly. Particle size plays a critical role in terms of biocompatibility and limits decisively its applicability. Producing reduced size microcapsules involves broadening ...
The synergistic effects of the RGD density and the microenvironment on the behavior of encapsulated cells: In vitro and in vivo direct comparative study
(John Wiley & Sons, 2014-11)
The inclusion of the tripeptide RGD (Arg-Gly-Asp) in otherwise inert biomaterials employed for cell encapsulation has been observed to be an effective strategy to provide the immobilized cells with a more suitable ...
Tendon tissue engineering: Cells, growth factors, scaffolds and production techniques
(Elsevier, 2021-05)
Tendon injuries are a global health problem that affects millions of people annually. The properties of tendons make their natural rehabilitation a very complex and long-lasting process. Thanks to the development of the ...
Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications
(MDPI, 2024-02-18)
Gene therapeutics are promising for treating diseases at the genetic level, with some already validated for clinical use. Recently, nanostructures have emerged for the targeted delivery of genetic material. Nanomaterials, ...