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Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies
(MDPI, 2021-06-07)
Methotrexate (MTX) is a mainstay therapeutic agent administered at high doses for the treatment of pediatric and adult malignancies, such as acute lymphoblastic leukemia, osteosarcoma, and lymphoma. Despite the vast evidence ...
A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
(Ivyspring International Publisher, 2019)
Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field ...
Combining random forests and physics-based models to forecast the electricity generated by ocean waves: A case study of the Mutriku wave farm
(Pergamon-Elsevier, 2019-10-01)
This paper combines random forests with physics-based models to forecast the electricity output of the Mutriku wave farm on the Bay of Biscay. The period analysed was 2014-2016, and the forecast horizon was 24 h in 4-h ...
Global estimations of wind energy potential considering seasonal air density changes
(Pergamon-Elsevier, 2019-11-15)
The literature typically considers constant annual average air density when computing the wind energy potential of a given location. In this work, the recent reanalysis ERA5 is used to obtain global seasonal estimates of ...
Problem-Based Learning in University Studies on Renewable Energies: Case of a Laboratory Windpump
(MDPI, 2020-03-23)
In the last eight years, the new faculty of Engineering in Renewable Energies at the University of the Basque Country in Eibar has developed several sustainability goals related to clean energy and climate change, but also ...
The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation
(MDPI, 2020-02-29)
The binding of Aβ42 peptide monomers to sphingomyelin/cholesterol (1:1 mol ratio) bilayers containing 5 mol% gangliosides (either GM1, or GT1b, or a mixture of brain gangliosides) has been assayed by density gradient ...
Exploring Polar Headgroup Interactions Between Sphingomyelin and Ceramide with Infrared Spectroscopy
(Nature, 2020-10-19)
Ceramide is a major actor in the sphingolipid signaling pathway elicited by various kinds of cell stress. Under those conditions ceramide (Cer) is produced in the plasma membrane as a product of sphingomyelin (SM) hydrolysis, ...
Neanderthal teeth from Lezetxiki (Arrasate, Iberian Peninsula): New insights and reassessment
(Wiley, 2023-04)
Objectives
We reassess the taxonomic assignment and stratigraphic context of a permanent upper first molar and a permanent lower third premolar recovered from the archeological site of Lezetxiki in the North of the ...
The return to the Iberian Peninsula: first Quaternary record of Muscardinus and a palaeogeographical overview of the genus in Europe
(Elsevier, 2015-05-18)
Although the earliest record of the genus Muscardinus dates from the Middle Miocene in Spain, no mention has been reported since the Lower Pliocene in the Iberian Peninsula. In this paper, Quaternary fossil remains of a ...
Bending rigidity, sound propagation and ripples in flat graphene
(Springer Nature, 2024-05-16)
Many of the applications of graphene rely on its uneven stiffness and high thermal conductivity, but the mechanical properties of graphene—and, in general, of all two-dimensional materials—are still not fully understood. ...