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Chronic social instability stress down-regulates IL-10 and up-regulates CX3CR1 in tumor-bearing and non-tumor-bearing female mice
(Elsevier, 2022-10)
Extensive literature has reported a link between stress and tumor progression, and between both of these factors and mental health. Despite the higher incidence of affective disorders in females and the neurochemical ...
Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2
(Wiley, 2010-03-10)
BACE2 is homologous to BACE1, a beta-secretase that is involved in the amyloidogenic pathway of amyloid precursor protein (APP), and maps to the Down syndrome critical region of chromosome 21. Alzheimer disease neuropathology ...
Engineering DYRK1A over-dosage yields Down syndrome-characteristic cortical splicing aberrations
(Elsevier, 2010-10)
Down syndrome (DS) associates with impaired brain functions, but the underlying mechanism(s) are yet unclear. The "gene dosage" hypothesis predicts that in DS, overexpression of a single gene can impair multiple brain ...
Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the Offspring
(The Endocrine Society, 2008-10-01)
Neurological deficits in the offspring caused by human maternal hypothyroxinemia are thought to be irreversible. To understand the mechanism responsible for these neurological alterations, we induced maternal hypothyroxinemia ...
Prevalence and risk factors of behavioural changes associated with age-related cognitive impairment in geriatric dogs
(Wiley, on behalf of the British Small Animal Veterinary Association, 2009)
Objectives: The aim of this study was to describe the prevalence and severity of behavioural changes associated with age and their relationship to risk factors such as sex, reproductive status, bodyweight and age.
Methods: ...
LRRK2 Expression is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1
(Springer, 2018)
Mutations in PINK1 (PARK6), a serine/threonine kinase involved in mitochondrial homeostasis, are associated with early onset Parkinson's disease. Fibroblasts from Parkinson's disease patients with compound heterozygous ...
In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model
(Springer, 2010-07-02)
Down syndrome, the most common genetic disorder leading to mental retardation, is caused by the presence of all or part of an extra copy of chromosome 21. At relatively early ages, Down syndrome patients develop progressive ...
Mitochondrial respiratory chain disorganization in Parkinson’s disease-relevant PINK1 and DJ1 mutants
(Elsevier, 2017-04-11)
Brain mitochondrial complex I (CI) damage is associated with the loss of the dopaminergic neurons of the Substantia Nigra in Parkinson's Disease (PD) patients. However, whether CI inhibition is associated with any alteration ...
The role of sociability in social instability stress: behavioral, neuroendocrine and monoaminergic effects
(Elsevier, 2023-10)
Extensive literature has reported a link between social stress and mental health. In this complex relationship, individual strategies for coping with social stress are thought to have a possible modulating effect, with ...
Generation of two transgene-free human iPSC lines from CD133+ cord blood cells
(Elsevier, 2019-02-28)
We have generated two human induced pluripotent stem cell (iPSC) lines from CD133+ cells isolated from umbilical cord blood (CB) of a female child using non-integrative Sendai virus. Here we describe the complete ...