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Perceived professional quality of life and mental well-being among animal facility personnel in Spain
(Sage, 2023-09-08)
Animal facility personnel provides the husbandry and care of laboratory animals.
We aimed to investigate their work-related quality of life, empathy, and mental well-being.
Participants living in Spain were contacted by ...
Chimeras for the twenty-first century
(Taylor & Francis, 2020-02-13)
Recent advances in stem cell biology and molecular engineering have improved and simplified the methodology employed to create experimental chimeras, highlighting their value in basic research and broadening the spectrum ...
The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity
(Springer Nature, 2024-01-17)
Fear-related pathologies are among the most prevalent psychiatric conditions, having inappropriate learned fear and resistance to extinction as cardinal features. Exposure therapy represents a promising therapeutic approach, ...
Buspirone anti-dyskinetic effect is correlated with temporal normalization of dysregulated striatal DRD1 signalling in L-DOPA-treated rats
(Elsevier, 2014-04)
Dopamine replacement with l-DOPA is the most effective therapy in Parkinson's disease. However, with chronic treatment, half of the patients develop an abnormal motor response including dyskinesias. The specific molecular ...
Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61) levels
(Wiley, 2015-08-28)
Brain-derived neurotrophic factor (BDNF) regulates synaptic strengthening and memory consolidation, and altered BDNF expression is implicated in a number of neuropsychiatric and neurodegenerative disorders. BDNF potentiates ...
Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease
(Elsevier, 2018-08-31)
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the huntingtin (htt) gene, which results in an aberrant form of the protein (mhtt). This leads to motor and ...
Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning
(Springer Nature, 2018-06-12)
Striatal-enriched protein tyrosine phosphatase (STEP) modulates key signaling molecules involved in synaptic plasticity and neuronal function. It is postulated that STEP opposes the development of long-term potentiation ...
Implementing strategies to reduce singly housed male mice
(Sage, 2019-05-01)
There are different husbandry situations that lead to social isolation of male mice. Besides legal considerations, single housing has a negative impact on behavioural and molecular studies. We have implemented two strategies, ...
Chronic defeat stress induces monoamine level dysregulation in the prefrontal cortex but not in the hippocampus of OF1 male mice
(Elsevier, 2024-06)
Chronic social stress can increase susceptibility to chronic diseases such as depression. One of the most used models to study the physiological mechanisms and behavioral outcomes of this type of stress is chronic defeat ...
Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition
(International Association for the Study of Pain, 2016-02)
The information from nociceptors is processed in the dorsal horn of the spinal cord by complex circuits involving excitatory and inhibitory interneurons. It is well documented that GluN2B and ERK1/2 phosphorylation contributes ...