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Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain
(BioMed Central, 2007-09)
Background: The presence of EGFR kinase domain mutations in a subset of NSCLC patients correlates with the response to treatment with the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Although most EGFR mutations ...
Influence of different dietary fats on triacylglycerol deposition in rat adipose tissue
(Cambridge University Press, 2000-11)
It has been demonstrated that triacylglycerol (TAG) mobilization from adipose tissue is selective and depends on fatty acid (FA) chain length, unsaturation and positional isomerism. The present study was performed to ...
Dietary fat source regulates ob gene expression in white adipose tissue of rats under hyperphagic feeding
(Cambridge University Press, 2002-05)
This work was designed to investigate the effect of different lipid sources on ob gene expression and serum leptin levels in rats with two different feeding protocols: (1) free access to food; or (2) energy-controlled ...
Effects of the whole seed and a protein isolate of faba bean (Vicia faba) on the cholesterol metabolism of hypercholesterolaemic rats
(Cambridge University Press, 2001-05)
The aim of the present work was to analyse the hypocholesterolaemic efficiency of a Vicia faba-protein isolate in relation to the intact legume. In addition, the mechanisms underlying the effects of this isolate were ...
Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients
(Public Library of Science, 2009-07-20)
Differences in gene expression patterns have been documented not only in Multiple Sclerosis patients versus healthy controls but also in the relapse of the disease. Recently a new gene expression modulator has been identified: ...
Prioritization of candidate cancer genes-an aid to oncogenomic studies
(Oxford University Press, 2008-10)
The development of techniques for oncogenomic analyses such as array comparative genomic hybridization, messenger RNA expression arrays and mutational screens have come to the fore in modern cancer research. Studies utilizing ...
Using reflective processes to promote attention to diversity in schools: a studv of practice in Chile
(2008)
[EN] Over the last decade or so, many writers have argued that inclusive practices are more likely to be developed when school communities are involved in collaborative processes of inquiry, reflection and action in order ...
trans-10, cis-12 Conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hamsters fed an atherogenic diet
(Cambridge University Press, 2006-06)
The aim of the present work was to investigate the effects of trans-10,cis-12conjugated linoleic acid (CLA) on the activity and expression of lipogenic enzymes and lipoprotein lipase (LPL), as well as on the expression of ...
Weak effect of trans-10, cis-12-conjugated linoleic acid on body fat accumulation in adult hamsters
(Cambridge University Press, 2009-12-14)
It has been proposed that young animals and subjects are more responsive to conjugated linoleic acid (CLA) than the adults. Nevertheless, there is very little information concerning the effectiveness of CLA in adult animals. ...
The trans-10,cis-12 isomer of conjugated linoleic acid reduces hepatic triacylglycerol content without affecting lipogenic enzymes in hamsters
(Cambridge University Press, 2004-09)
Conjugated linoleic acid (CLA) refers to the positional and geometric dienoic isomers of linoleic acid. The dietary intake of CLA has been associated with changes in lipid metabolism. The aim of the present work was to ...