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Non-Pharmacological Strategies for Self-Directed and Interpersonal Violence in People with Severe Mental Illness: a Rapid Overview of Systematic Reviews
(BMJ Publishing Group, 2021)
Introduction Self-directed and interpersonal violence among people with severe mental illness has become a health priority. Though non-pharmacological interventions have been investigated, to our knowledge, no summary of ...
Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores
(Springer, 2021-06-07)
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ...
Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy
(Elsevier, 2021-12-03)
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by expansion of unstable CTG repeats in a non-coding region of the DMPK gene. CUG expansions in mutant DMPK transcripts sequester MBNL1 proteins in ...
Quantifying the patients perspective in neuromyelitis optica spectrum disorder: Psychometric properties of the SymptoMScreen questionnaire
(Public Library Of Science, 2021-07-29)
BACKGROUND: The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire ...
Oral and Palmitate Paliperidone Long-Acting Injectable Formulations’ Use in Schizophrenia Spectrum Disorders: A Retrospective Cohort Study from the First Episode Psychosis Intervention Program (CRUPEP)
(Oxford University Press, 2021)
Background: Long-acting injectable antipsychotics (LAIs) may be a suitable therapeutic option for those patients in earlier stages of psychosis to avoid relapses and disease progression. Despite that, there is a lack of ...
External surface anatomy of the postfolding human embryo: Computer-aided, three-dimensional reconstruction of printable digital specimens
(2021-12)
Opportunities for clinicians, researchers, and medical students to become acquainted with the three-dimensional (3D) anatomy of the human embryo have historically been limited. This work was aimed at creating a collection ...
Embedding interactive, three-dimensional content in portable document format to deliver gross anatomy information and knowledge
(Wiley, 2021-09)
The Portable Document Format (PDF) is likely the most widely used digital file format for scholarly and scientific electronic publishing. Since format specification version 1.6, three-dimensional (3D) models in Universal ...
Local translation in nervous system pathologies
(Frontiers Media, 2021-06-29)
[EN] Dendrites and axons can extend dozens to hundreds of centimeters away from the
cell body so that a single neuron can sense and respond to thousands of stimuli.
Thus, for an accurate function of dendrites and axons ...
Mens sana in corpore sano: lifestyle changes modify astrocytes to contain Alzheimer’s disease
(Wolters Kluwer, 2021-08)
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
(2021-03)
Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive ...