Search
Now showing items 10641-10650 of 10674
alpha-Branched Ketone Dienolates: Base-Catalyzed Generation and Regio- and Enantioselective Addition Reactions
(Wiley-VCH, 2019-05-14)
In this study, the unique capacity of bifunctional Brønsted bases to generate α-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon ...
Catalytic Asymmetric α-Functionalization of α-Branched Aldehydes
(MDPI, 2023-03-16)
Aldehydes constitute a main class of organic compounds widely applied in synthesis. As such, catalyst-controlled enantioselective α-functionalization of aldehydes has attracted great interest over the years. In this context, ...
Reducing Negative Aging Stereotypes via Educational Intervention in Older People: A Randomized Controlled Study
(Sage, 2022-09-13)
Anti-ageism interventions traditionally target younger individuals. We analyzed the effect of an educational intervention that combined an infusion of aging content with videos to reduce negative stereotypes toward aging ...
Organocatalytic Michael Addition of Unactivated α-Branched Nitroalkanes to Afford Optically Active Tertiary Nitrocompounds
(ACS, 2023-11-27)
The direct, asymmetric conjugate addition of unactivated α-branched nitroalkanes is developed based on the combined use of chiral amine/ureidoaminal bifunctional catalysts and a tunable acrylate template to provide tertiary ...
Synthesis of 4,6-Difluoro-Tryptophan as a Probe for Protein 19F NMR
(Wiley-VCH GmbH, Weinheim, 2024-03-25)
A scalable procedure for the synthesis of 4,6-difluorotryptophan is reported based on a deaminative
coupling of a 4,6-difluorogramine with 2-benzylthio-1,5-dihydro-4H-imidazolone as glycine equivalent. Thus prepared ...
Development of an α’-hydroxy enone for the aminocatalytic asymmetric formal conjugate addition of aldehydes to acrylates, vinyl ketones and acrolein
(Royal Society of Chemistry, 2023-05-24)
Aminocatalytic asymmetric conjugate addition of aldehydes to Michael acceptors is a well established C–C bond forming methodology. However, various acrylic-type acceptors, including acrylic acid derivatives and acrolein, ...
Progress in (Thio)urea‐ and Squaramide‐Based Brønsted Base Catalysts with Multiple H‐Bond Donors
(Wiley, 2023-02)
Nowadays chiral (thio)urea- and squaramide-based Brønsted base catalysts are widely applied to enantioselective carbon-carbon and carbon-heteroatom bond forming reactions. In recent years, variations of these catalysts ...
The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits
(2015-05-27)
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular,
height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research.
However, ...
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study
(Elsevier, 2016-07-13)
Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the ...