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Additive and Emergent Catalytic Properties of Dimeric Unnatural Amino Acid Derivatives: Aldol and Conjugate Additions.
(Wiley, 2021-11-11)
[EN]Different densely substituted L- and D-proline esters were prepared by asymmetric (3+2) cycloaddition reactions catalyzed by conveniently selected EhuPhos chiral ligands. The gamma-nitro-2-alkoxycarbonyl pyrrolidines ...
Phenanthrene-Extended Phenazine Dication: An Electrochromic Conformational Switch Presenting Dual Reactivity
(American Chemical Society, 2022)
The synthesis and isolation of one of the few examples of a pi-extended diamagnetic phenazine dication have been achieved by oxidizing a phenanthrene-based dihydrophenazine precursor. The resulting dication was isolated ...
Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor
(Beilstein Institut, 2011-07)
The synthesis of a GSK 2(nd) generation inhibitor of the hepatitis C virus, by enantioselective 1,3-dipolar cycloaddition between a leucine derived iminoester and tert-butyl acrylate, was studied. The comparison between ...
Synthetic scope and DFT analysis of the chiral binap-gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes
(Beilstein Institut, 2013-11)
he 1,3-dipolar cycloaddition between glycine-derived azlactones with maleimides is efficiently catalyzed by the dimeric chiral complex [(S-a)-Binap.AuTFA](2). The alanine-derived oxazolone only reacts with tert-butyl ...
Towards a more precise therapy in cancer: Exploring epigenetic complexity
(Elsevier, 2020-08)
A plethora of preclinical evidences suggests that pharmacological targeting of epigenetic dysregulation is a potent strategy to combat human diseases. Nevertheless, the implementation of epidrugs in clinical practice is ...
Enantioselective Ring-Opening Polymerization of rac-Lactide Dictated by Densely Substituted Aminoacids
(ACS, 2017-03-08)
Organocatalysis is becoming an important tool in
polymer science because of its versatility and specificity. To date
a limited number of organic catalysts have demonstrated the
ability to promote stereocontrolled ...
Boosting background suppression in the NEXT experiment through Richardson-Lucy deconvolution
(Springer, 2021-07-21)
Next-generation neutrinoless double beta decay experiments aim for half-life sensitivities of similar to 10(27) yr, requiring suppressing backgrounds to < 1 count/tonne/yr. For this, any extra background rejection handle, ...
Bicolour fluorescent molecular sensor for cations: design and experimental validation
(Royal Society of Chemistry, 2021-07-02)
Molecular entities whose fluorescence spectra are different when they bind metal cations are termed
bicolour fluorescent molecular sensors. The basic design criteria of this kind of compound are presented
and the different ...
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
(Wiley, 2020-09-22)
Background and Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of symptomatic biliary cysts. Current surgical and pharmacological approaches are ineffective, and liver ...
Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(II) and copper(II) complex
(Royal Society of Chemistry, 2017-08-11)
A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides. The catalytic system is based on the distortion of the double ...