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Disruption of Oligodendrocyte Progenitor Cells is an Early Sign of Pathology in the Triple Transgenic Mouse Model of Alzheimer's Disease
(Elsevier, 2020-10)
There is increasing evidence that myelin disruption is related to cognitive decline in Alzheimer's disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by adult oligodendrocyte ...
Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways
(MDPI, 2021-03-04)
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. ...
The Anti-Inflammatory Astrocyte Revealed: the Role of the Microbiome in Shaping Brain Defences
(Springer, 2021-04-10)
Astrocytes are a sub-type of neuroglia responsible for homoeostasis and defence of the nervous system. Pathological reactions of neuroglial cells in various neurological disorders have been identified and characterised in ...
Mens sana in corpore sano: lifestyle changes modify astrocytes to contain Alzheimer’s disease
(Wolters Kluwer, 2021-08)
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
(2021-03)
Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive ...
Lifestyle-dependent microglial plasticity: training the brain guardians
(BMC, 2021-08-03)
Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All ...
Astrocytic Atrophy as a Pathological Feature of Parkinson's Disease with LRRK2 Mutation
(Springer, 2021-03-30)
The principal hallmark of Parkinson's disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to dopaminergic neurodegeneration through decreased ...