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Co-Catalyzed C(sp3)−H Oxidative Coupling of Glycine and Peptide Derivatives
(American Chemical Society, 2017-09-22)
obalt-catalyzed selectiveα-alkylation andα-heteroarylation processes ofα-amino esters and peptide derivativesare described. These cross-dehydrogenative reactions occur undermild conditions and allow for the rapid assembly ...
Site-Selective Trifluoromethylation Reactions of Oligopeptides
(Wiley, 2020-06-08)
Site-selective chemical modifications that target proteinogenic amino acid residues complement the methods entailing genetic manipulation, thereby allowing straightforward and rapid access to engineered proteins. The ...
Metal-catalyzed C–H functionalization processes upon “click”-triazole assistance
(Wiley, 2018-08-24)
The functionalization of otherwise unreactive C–H bonds holds great promise for reducing the reliance on existing functional groups while improving energy efficiency and atom-economy. One of the most powerful strategies ...
Iron-Catalyzed C(sp3)−H Functionalization of N,N-Dimethylanilines with Isocyanides
(Royal Society of Chemistry, 2018-01-22)
An efficient ligand-free Fe-catalyzed oxidative Ugi-type reaction toward the assembly of α-amino amides and short peptides is described. The reaction proceeds through the α-C(sp3)−H oxidation of N,N-dimethylanilines and ...
Cu-Catalyzed Site-Selective C(sp2)–H Radical Trifluoromethylation of Tryptophan Containing Peptides
(ACS Publications, 2020-02-13)
Site-selective functionalization of C–H bonds within a peptide framework poses a challenging task of paramount synthetic relevance. Herein, we report an operationally simple C(sp2)–H trifluoromethylation of tryptophan ...