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Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients
(Elsevier, 2018-08)
Background: Sepsis is a life-threatening illness with a challenging diagnosis. Current serum biomarkers are not sensitive enough for diagnosis. With the aim of finding proteins associated with sepsis, serum protein profile ...
A Three-Protein Panel to Support the Diagnosis of Sepsis in Children
(MDPI, 2022-03-12)
Sepsis is a syndrome without a standard validated diagnostic test. Early recognition is crucial. Serum proteome analysis in children with sepsis may identify new biomarkers. This study aimed to find suitable blood biomarkers ...
Influence of Calcium Ion-Modified Implant Surfaces in Protein Adsorption and Implant Integration
(Springer, 2021-04-21)
Background Calcium (Ca) is a well-known element in bone metabolism and blood coagulation. Here, we investigate the link between the protein adsorption pattern and the in vivo responses of surfaces modified with calcium ...
Antibacterial and antifungal activity of the human endometrial fluid during the natural cycle
(Hindawi, 2021-06-16)
[EN] Purpose. Some microbiota patterns have been associated with favorable IVF prognosis and others with pathological conditions. The
endometrial fluid aspirate (EFA) contains antibacterial proteins that are enriched in ...
Protein adsorption/desorption dynamics on Ca-enriched titanium surfaces: biological implications
(Springer, 2021-08-27)
Calcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant ...
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
(BMJ Publishing Group, 2021-06-07)
[EN] Objective Hepatocellular carcinoma (HCC) is a prevalent
and aggressive cancer usually arising on a background
of chronic liver injury involving inflammatory and hepatic
regenerative processes. The triggering receptor ...
Potential Tear Biomarkers for the Diagnosis of Parkinson’s Disease—A Pilot Study
(MDPI, 2022-01-13)
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, n = 24), carriers of the E46K-SNCA ...
Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
(Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ...
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
(Sage, 2021-09)
Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed ...
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
(Elsevier, 2019-08-16)
Objective: Non-alcoholic fatly liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metabolic pathways, mitochondrial functionality and unbalanced lipid import/export, lead ...